Results 131 to 140 of about 137,818 (293)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Microstrip Configurations of Reflective-Mode Phase-Variation Permittivity Sensors Based on Weakly Coupled Step Impedance Resonators (SIR): An Analysis to the Light of Circuit Duality

IEEE Access
This paper presents and experimentally validates various topologies of one-port reflective-mode phase-variation permittivity sensors based on weakly coupled step impedance resonators (SIRs), the sensing elements, implemented in microstrip technology. The differences between such topologies concern the specific configuration, either series or parallel ...
Joaquím Borràs-Sarsa, Pau Casacuberta, Paris Vélez, Lijuan Su, Xavier Canalias, Ferran Martín   +5 more
openaire   +3 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Multi-sensor data fusion for urban area classification

, 2011
Nowadays many sensors for information acquisition are widely employed in remote sensing and different properties of the objects can be revealed. Unfortunately each imaging sensor has its own limits on scene recognition in the sense of thematic, temporal,
Palubinskas, Gintautas, Gintautas Palubinskas, Reinartz, Peter, Makarau, Aliaksei, Aliaksei Makarau, Peter Reinartz   +5 more
core   +1 more source

Covariate-adjusted functional data analysis for structural health monitoring

Data-Centric Engineering
Structural health monitoring (SHM) is increasingly applied in civil engineering. One of its primary purposes is detecting and assessing changes in structure conditions to increase safety and reduce potential maintenance downtime.
Philipp Wittenberg, Lizzie Neumann, Alexander Mendler, Jan Gertheiss   +3 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

A Thin-Film Heat Flux Sensor Fabricated on Copper for Heat Transfer Measurements in Parallel Channel Heat Sinks

, 2010
A combination of lithography-based microfabrication and micro end milling is used to manufacture thin-film resistance temperature detector (RTD) heat flux sensors on bulk copper substrates.
Jasperson, Benjamin A., Turner, Kevin T., Pfefferkorn, Frank E., Qu, Weilin   +3 more
core  

Laser‐Induced in situ Synthesis and Assembly of Nano‐Cotton TiO2 Humidity Sensors with High Sensitivity and Fast Response for Real‐Time Respiratory Monitoring

Small Structures
Humidity sensors functioned by 1D nanostructural metal oxides (1D NMOs) are promising for real‐time respiratory monitoring. However, the preparation and assembly of 1D NMOs on sensor structures are quite challenging due to the complicated synthesis ...
Zhichao Yu, Juqing Li, Qiurui Zhang, Pei Xiang, Jincheng Lei   +4 more
doaj   +1 more source