Results 111 to 120 of about 127,919 (291)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
A simple and wavelength-flexible procedure for fabricating phase-shifted fibre Bragg gratings [PDF]
, 2010 A simple procedure for fabricating phase-shifted fibre Bragg gratings (PSFBGs) that does not require the use of a phase-shifted phase mask is presented.
Tatam, Ralph P. +5 more
core +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Theoretical mass, liquid, and polymer sensitivity of acoustic wave sensors with viscoelastic guiding layers [PDF]
, 2003 The theoretical sensitivity of Love wave and layer-guided shear horizontal acoustic plate mode (SH-APM) sensors for viscoelastic guiding layers and general loading by viscoelastic materials is developed.
Fabrice Martin +8 more
core +1 more source
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2015 This study aimed to evaluate the influence of the track surface on which horses are examined, regarding the phase of lameness presentation. Ten horses with lameness in at least one limb were evaluated with wireless inertial sensors on three track ...
M.S. Azevedo +7 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Understanding and Ameliorating Non-Linear Phase and Amplitude Responses in AMCW Lidar
, 2011 Amplitude modulated continuous wave (AMCW) lidar systems commonly suffer from non-linear phase and amplitude responses due to a number of known factors such as aliasing and multipath inteference. In order to produce useful range and intensity information
Michael J. Cree +5 more
core +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source