Results 131 to 140 of about 28,526,403 (303)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
CrystalsThis study is focused on the sorption properties and the changes in the structure and state of Ti-25Al-25Nb (at.%) system alloys under thermal cyclic loading.
Yernat Kozhakhmetov +6 more
doaj +1 more source
Wavelet coherence phase analysis decodes the universal switching mechanism of Ras GTPase superfamily. [PDF]
iScience, 2023 Motiwala Z +3 more
europepmc +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Two-phase flow experimental studies in micro-models [PDF]
, 2013 The aim of this research project was to put more physics into theories of two-phase flow. The significance of including interfacial area as a separate variable in two-phase flow and transport models was investigated.
Physically-based theory of two-phase flow in porous media including fluid-fluid interfacial area +2 more
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Particle and Phase Analysis of Combusted Iron Particles for Energy Storage and Release. [PDF]
Materials (Basel), 2023 Buchheiser S +8 more
europepmc +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Analysis of Output Current Ripple of Three-phase PWM Inverter under Discontinuous Modulation Techniques [PDF]
, 2010 In this paper, an analysis of output current ripple of three-phase PWM inverters with discontinuous modulation is presented. The analytical expressions for discontinuous modulation injection signal are derived.
Dahono, Pekik Argo
core
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source