Results 171 to 180 of about 3,995,176 (315)

Dose selection in seamless phase II/III clinical trials based on efficacy and toxicity [PDF]

Seamless phase II/III clinical trials are attractive in development of new drugs because they accelerate the drug development process. Seamless phase II/III trials are carried out in two stages.
Kimani, Peter K.
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Phase Analysis and Thermoelectric Properties of Cu-Rich Tetrahedrite Prepared by Solvothermal Synthesis. [PDF]

Materials (Basel), 2022
Zazakowny K, Kosonowski A, Lis A, Cherniushok O, Parashchuk T, Tobola J, Wojciechowski KT.   +6 more
europepmc   +1 more source

Phases of Data Analysis

EDIS, 2015
This document outlines the phases of data analysis for evaluating Extension programs, emphasizing the importance of tailoring the process to available resources and evaluation rigor. It covers steps such as screening data for errors, selecting key impact indicators, measuring and testing changes, comparing participant groups, and elaborating program ...
openaire   +1 more source

Capillary electrophoresis and hydrophilic interaction chromatography coupled to mass spectrometry for anionic metabolic profiling

, 2014
Metabolomics encompasses the identification and quantification of low-molecular weight endogenous metabolites in biological samples, such as cells, tissues and body fluids.
Sub Biomolecular analysis, Kok, M.G.M., Biomolecular Analysis, Molecular Pharmacy   +3 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Utilizing Raman Spectroscopy as a Tool for Solid- and Solution-Phase Analysis of Metalloorganic Cage Host-Guest Complexes. [PDF]

Inorg Chem, 2023
O'Connor HM, Tipping WJ, Vallejo J, Nichol GS, Faulds K, Graham D, Brechin EK, Lusby PJ.   +7 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Structure and phase analysis of calcium carbonate powder prepared by a simple solution method. [PDF]

Heliyon, 2021
Febrida R, Setianto S, Herda E, Cahyanto A, Joni IM.   +4 more
europepmc   +1 more source

Phase Analysis [PDF]

, 2020
openaire   +1 more source