Results 51 to 60 of about 5,504,773 (297)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Mineralogical characterization of the flotation products using automated mineral liberation analysis at the Erdenetiin Ovoo Cu-Mo porphyry deposit, Mongolia

Mongolian Geoscientist
The flotation process is used to extract copper-molybdenum sulfide minerals from ore. The selection of the flotation technology scheme largely depends on factors such as the composition of sulfide ore in the ore body, grain size, and characteristics of ...
Batmunkh Tumen-Ayush, Chinzorig Bavuu, Narangerel Adiyasuren, Ganbileg Davaajav, Davaadulam Batbileg, Sondor Ganbat, Tsend-Ayush Tserendagva, Altankhuyag Dorjyunden, Ganzorig Chimed   +8 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Time-like entanglement entropy in AdS/BCFT

Journal of High Energy Physics, 2023
We study the entanglement entropy for time-like subsystem in two-dimensional boundary conformal field theory (BCFT) both from the field theory and holographic point of view.
Chong-Sun Chu, Himanshu Parihar
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Ferrite-to-Austenite and Austenite-to-Martensite Phase Transformations in the Vicinity of a Cementite Particle: A Molecular Dynamics Approach

Metals, 2018
We used classical molecular dynamics simulation to study the ferrite–austenite phase transformation of iron in the vicinity of a phase boundary to cementite.
Jerome Meiser, Herbert M. Urbassek
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Modulation of phase boundary and domain structures to engineer strain properties in BNT-based ferroelectrics

Journal of Advanced Ceramics
Bismuth sodium titanate (BNT) ceramics exhibit outstanding strain responses but are unfavorable for application in high-sensitivity displacement actuators due to the large negative strain resulting from irreversible changes in their phase transition and ...
Yule Yang, Zhiyong Liu, Pengrong Ren, Yuqing Mao, Haijun Sun, Bingliang Liang, Pu Mao, Kun Guo, Bing Xie, Longlong Shu   +9 more
doaj   +1 more source

Physiological Importance of Phase Boundaries—II [PDF]

Scientific American, 1916
n ...
openaire   +1 more source