Results 61 to 70 of about 5,504,773 (297)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Micromechanical response of fibre-reinforced materials using the boundary element technique [PDF]

, 2003
The Boundary Element Method (BEM) and the Embedded Cell Approach (ECA) have been used to analyse the effects of constituent material properties and fibre spatial distribution on the localised behaviour of a transversely loaded, unidirectional fibre ...
Knight, MG, Wrobel, LC, Henshall, JL
core   +4 more sources

Lath martensite plasticity enabled by apparent sliding of substructure boundaries

Materials & Design, 2019
Lath martensite is widely present in advanced high strength steels as the key strengthening phase. Unexpectedly high ductility of lath martensite has been reported in the literature in both single-phase and multi-phase steels, however, without systematic
C. Du, R. Petrov, M.G.D. Geers, J.P.M. Hoefnagels   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Fluctuations of the Phase Boundary in the 2D Ising Ferromagnet [PDF]

, 1997
We discuss some statistical properties of the phase boundary in the 2D low-temperature Ising ferromagnet in a box with the two-component boundary conditions.
R. Dobrushin, Hryniv, O., Dobrushin, Roland, O. Hryniv, Hryniv, Ostap, Dobrushin, R.   +5 more
core   +1 more source

Effect of grain boundary phase on the magnetization reversal process of nanocrystalline magnet using large-scale micromagnetic simulation

AIP Advances, 2018
We investigated the effects of grain boundary phases on magnetization reversal in permanent magnets by performing large-scale micromagnetic simulations based on Landau–Lifshitz–Gilbert equation under a periodic boundary.
Hiroshi Tsukahara, Kaoru Iwano, Chiharu Mitsumata, Tadashi Ishikawa, Kanta Ono   +4 more
doaj   +1 more source

Corrosion behavior of Mg–Gd–Zn based alloys in aqueous NaCl solution

Journal of Magnesium and Alloys, 2014
The corrosion behavior of Mg-10Gd–xZn (x = 2, 6 wt.%) alloys in 0.5 wt.% NaCl solution was investigated. Microstructures of both the alloys consisted of (Mg,Zn)3Gd phase and lamellar long period stacking ordered (LPSO) phase. The morphology of the second
A. Srinivasan, C. Blawert, Y. Huang, C.L. Mendis, K.U. Kainer, N. Hort   +5 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source