Results 161 to 170 of about 1,022,362 (318)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Properties and phase composition of cement mortars

Introduction of complex antifreezes based on calcium formate, calcium chloride and superplasticizer Polyplast SP-1 into cement masses leads to changes in the phase composition of cement mortars.
V. V. Schmidt, L. N. Makarova, V. V. Makarov, A. V. Ismagilova   +3 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Multicomponent phase diagrams : applications for commercial aluminum alloys /

, 2005
Despite decades of extensive research and application, commercial aluminum alloys are still poorly understood in terms of the phase composition and phase transformations occurring during solidification, cooling, and heating. Multicomponent Phase Diagrams:
Eskin, D. G., Aksenov, A. A., Belov, N. A.   +2 more
core  

The peculiarities of the quasi-eutectic phase composition

, 2006
Досліджено особливості фазового складу квазіевтектик при кристалізації рідини й аморфного стану. Розглянуто термодинамічні параметри систем і показано, що при квазіевтектичній кристалізації рідини фазовий склад квазіевтектики залежить від розчинності ...
Спиридонова, І.М., Береза, О.Ю.   +1 more
core   +1 more source

Influence of the Phase Composition of Titanium Alloys on Cell Adhesion and Surface Colonization. [PDF]

Materials (Basel), 2023
Straumal BB, Anisimova NY, Kiselevskiy MV, Novruzov KM, Korneva A, Gornakova AS, Kilmametov AR, Sommadossi S, Davdian G.   +8 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Manganese Ferrite Containing Glass-Crystalline Materials-Phase Composition, Microstructure and Magnetic Properties. [PDF]

Materials (Basel)
Takov P, Harizanova R, Mihailova I, Bancheva-Koleva P, Avdeev G, Paneva D, Cherkezova-Zheleva Z, Georgieva M, Karadimov T, Rüssel C.   +9 more
europepmc   +1 more source