Results 181 to 190 of about 26,153,681 (361)

Atoms in intense ultrashort laser pulses and the absolute phase [PDF]

open access: yes, 2004
Diese Arbeit beschäftigt sich mit der experimentellen Analyse atomarer Prozesse in intensiven ultrakurzen Laserpulsen. Der Schwerpunkt liegt hierbei bei den Zwillingseffekten der Erzeugung hoher Harmonischer (``high-order harmonic generation'', HHG) und ...
Lindner, F., Lindner, Fabrizio
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Which parameters control the leg movement of a walking insect?: I. Velocity control during the stance phase

open access: yes, 1985
Cruse H. Which parameters control the leg movement of a walking insect?: I. Velocity control during the stance phase. The journal of experimental biology.
Cruse, Holk
core  

Proton beam quality enhancement by spectral phase control of a PW-class laser system. [PDF]

open access: yesSci Rep, 2021
Ziegler T   +26 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Research on Program-controlled Power Source Based on DDS

open access: yesJournal of Measurement Science and Instrumentation, 2011
Direct Digital Synthesis(DDS)chip was used in the design of program controlled power source in this paper.With the accurate control of Dual DDS chips by Micro Controller Unit(MCU),filter and power amplifier,this power source can generate voltage and ...
Xue-wei YANG1   +4 more
doaj  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

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