Results 71 to 80 of about 1,626,663 (291)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Baseline correction of phase-contrast images in congenital cardiovascular magnetic resonance

Journal of Cardiovascular Magnetic Resonance, 2010
Background One potential source of error in phase contrast (PC) congenital CMR flow measurements is caused by phase offsets due to local non-compensated eddy currents.
Lai Wyman W, Printz Beth F, Holland Brian J   +2 more
doaj   +1 more source

Ellipticity corrections for seismic phases [PDF]

Geophysical Journal International, 1996
SUMMARY The advent of broad-band seismology has meant that use is being made of a wide range of seismic phases, for many of which ellipticity corrections have not been readily available. In particular, when many seismic phases are used in location schemes, it is important that the systematic effects of ellipticity are included for each phase.
B. L. N. Kennett, O. Gudmundsson
openaire   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Systematic Review of Phase Aberration Correction Algorithms for Transcranial Focused Ultrasound

iRADIOLOGY
Transcranial focused ultrasound (tFUS) is an emerging modality with strong potential for non‐invasively treating brain disorders. However, the inhomogeneity and complex structure of the skull induce substantial phase aberrations and pressure attenuation;
Mingyu Wang, Zhouyang Xu, Bingbing Cheng
doaj   +1 more source

Weak localization effects in granular metals

, 2005
The weak localization correction to the conductivity of a granular metal is calculated using the diagrammatic technique in the reciprocal grain lattice representation.
A. A. Varlamov, B. L. Al’tshuler, C. Biagini, J. Rammer, T. Caneva, V. Tognetti   +5 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Automatic Phase Correction of NMR Spectra Using Brute-Force GPU Method

Inventions
Although there are still no fully guaranteed solutions to the problem of phase adjustment of NMR spectroscopy signals, it has not received much consideration recently, especially in the presence of noisy signals.
Mario Gazziro, Marcio Luís Munhoz Amorim, Marco Roberto Cavallari, João Paulo Carmo, Alberto Tannus, Oswaldo Hideo Ando Junior, Loren Schwiebert   +6 more
doaj   +1 more source