Results 141 to 150 of about 12,307,516 (339)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Transições de fase na matéria de quarks magnetizada com repulsão vetorial [PDF]

, 2015
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Física, Florianópolis, 2015.Neste trabalho investigamos as transições de fase na matéria de quarks magnetizada usando o ...
Denke, Robson Zacarelli
core  

Phase diagram and thermodynamic modeling of PEO + organic salts + H2O and PPO + organic salts + H2O aqueous two-phase systems

, 2015
The phase diagrams of PEO1500 + sodium tartrate + water, PPO400 + sodium tartrate + water, PEO1500 + sodium succinate + water, PPO400 + sodium succinate + water, PEO1500 + sodium citrate + water, PPO400 + sodium citrate + water and PPO400 + sodium ...
Silva, Luis Henrique Mendes da, Mageste, Aparecida Barbosa, Carvalho, Raquel Moreira Maduro de, Patrício, Pamela da Rocha, Lemos, Leandro Rodrigues de, Silva, Maria C. Hespanhol da   +5 more
core   +1 more source

Unconventional superconducting phase diagram of monolayer WTe_{2}

Physical Review Research
The existence of a quantum critical point (QCP) and fluctuations around it are believed to be important for understanding the phase diagram in unconventional superconductors such as cuprates, iron pnictides, and heavy fermion superconductors.
Tiancheng Song, Yanyu Jia, Guo Yu, Yue Tang, Ayelet J. Uzan, Zhaoyi Joy Zheng, Haosen Guan, Michael Onyszczak, Ratnadwip Singha, Xin Gui, Kenji Watanabe, Takashi Taniguchi, Robert J. Cava, Leslie M. Schoop, N. P. Ong, Sanfeng Wu   +15 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Chaotic phase diagram with Multisim.

, 2016
(a)xy phase diagram, (b) xz phase diagram, (c) zy phase diagram.
Xin-Guo Zhang (3070731), Yan-Jun Lu (3070725), Yong-Fang Zhang (3070722), Parag Gupta (3070728), Li Xiong (694078)   +4 more
core   +1 more source

Bubble dynamics in a QCD-like phase diagram

Journal of High Energy Physics
A line of first-order phase transitions is conjectured in the phase diagram of Quantum Chromodynamics at non-zero baryon density. If this is the case, numerical simulations of neutron star mergers suggest that various regions of the stars may cross this ...
Yago Bea, Mauro Giliberti, David Mateos, Mikel Sanchez-Garitaonandia, Alexandre Serantes, Miguel Zilhão   +5 more
doaj   +1 more source

Experimental phase diagram for random laser spectra

New Journal of Physics, 2012
We systematically study the presence of narrow spectral features in a wide variety of random laser samples. Less gain or stronger scattering are shown to lead to a crossover from spiky to smooth spectra. A decomposition of random laser spectra into a set
Ramy G S El-Dardiry, Ronald Mooiweer, Ad Lagendijk   +2 more
doaj   +1 more source