Results 161 to 170 of about 1,904,886 (283)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Synthesis of Poly(Lactic Acid-<i>co</i>-Arginine) and Construction of Its Ternary Phase Diagram for Nonsolvent Induced Phase Separation. [PDF]

Materials (Basel)
Zhu Y, Yan H, Wang B, Shangguan Z, Yao J.   +4 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Phase Diagrams

, 2006
  +5 more sources

Saturation of superconductivity in cuprates overdoped with high-pressure oxygen: Phase diagram with YBa₂Cu₃O_7+δ, δ → 1. [PDF]

Proc Natl Acad Sci U S A
Conradson SD, Dezaneti LM, Baldinozzi G, Sederholm L, Karppinen M, Casillas-Trujillo L, Latimer M, Mueller O, Gilioli E, Bishop AR, Guo X, Liu J, Lezama Pacheco J.   +12 more
europepmc   +1 more source

Phase Diagram and Quantum Entanglement Properties of a Pentamer S = 1/2 Heisenberg Spin Cluster. [PDF]

Molecules, 2023
Szałowski K.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Efficient Determination of Water/Ice Phase Diagram through Isenthalpic-Isobaric Molecular Dynamics Simulations. [PDF]

J Phys Chem B
Weidmann AB, Mercier Franco LF, Sum AK, Pessôa Filho PA.   +3 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Calculating a Phase Diagram of a Simple Water Model Using Unsupervised Machine Learning on Simulation Data. [PDF]

J Chem Theory Comput
Ogrin P, Urbic T.
europepmc   +1 more source