Results 171 to 180 of about 569,956 (263)

Nonequilibrium phase diagram for the serration statistics during slow deformation of refractory high-entropy alloys. [PDF]

Sci Rep
Liu MW, Hsu WC, Chiang TY, Tsai CW, Dahmen KA.   +4 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Transport phase diagram and anomalous metallicity in superconducting infinite-layer nickelates. [PDF]

Nat Commun
Hsu YT, Lee K, Badoux S, Duffy C, Cuoghi A, Wang BY, Kool A, Haïk-Dunn I, Hwang HY, Hussey NE.   +9 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Phase Diagram of 2D Poly(Ethylene Oxide)-<i>block</i>-Poly(Propylene Oxide)-<i>block</i>-Poly(Ethylene Oxide)─Poly(Dimethylsiloxane) Blends: A Combined Neutron Reflectometry and Sum Frequency Generation Study. [PDF]

Langmuir
Araminthe A, El Haitami A, Kővágó B, Cousin F, Sanchez-Puga P, Webster JRP, Gutfreund P, Backus EHG, Cantin S.   +8 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Medium-density amorphous ice unveils shear rate as a new dimension in water's phase diagram. [PDF]

Proc Natl Acad Sci U S A
de Almeida Ribeiro I, Dhabal D, Kumar R, Banik S, Sankaranarayanan SKRS, Molinero V.   +5 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Discontinuous phase diagram of amorphous carbons. [PDF]

Natl Sci Rev
Zhu Y, Fang Z, Zhang Z, Wu H.
europepmc   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source