Results 81 to 90 of about 1,844,634 (338)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Phase diagram of the SU(2) Kondo lattice

AIP Advances, 2018
We examine the SU(2) Kondo Lattice Model, for simple cubic lattices with various magnitudes of the localized spins j and numbers of conduction electrons, nc. For j=1/2, the system undergoes transitions from the paramagnetic to magnetically ordered states.
Miguel Abele, P. S. Riseborough
doaj   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Defect phase diagram for doping of Ga2O3

APL Materials, 2018
For the case of n-type doping of β-Ga2O3 by group 14 dopants (C, Si, Ge, Sn), a defect phase diagram is constructed from defect equilibria calculated over a range of temperatures (T), O partial pressures (pO2), and dopant concentrations.
Stephan Lany
doaj   +1 more source

Overdoped end of the cuprate phase diagram

Physical Review Research, 2020
Studying the disappearance of superconductivity at the end of the overdoped region of the cuprate phase diagram offers a different approach for investigating the interaction which is responsible for pairing in these materials.
Thomas A. Maier, Seher Karakuzu, Douglas J. Scalapino   +2 more
doaj   +1 more source

Exploring the QCD phase diagram [PDF]

, 2012
Lattice simulations employing reweighting and Taylor expansion techniques have predicted a (m;T)-phase diagram according to general expectations, with an analytic quark-hadron crossover at m =0 turning into a first order transition at some critical ...
Philipsen, Owe
core  

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Phase diagram for strong-coupling Bose polarons

SciPost Physics
Important properties of complex quantum many-body systems and their phase diagrams can often already be inferred from the impurity limit. The Bose polaron problem describing an impurity atom immersed in a Bose-Einstein condensate is a paradigmatic ...
Arthur Christianen, J. Ignacio Cirac, Richard Schmidt
doaj   +1 more source

Equilibrium glassy phase in a polydisperse hard sphere system

, 2005
The phase diagram of a polydisperse hard sphere system is examined by numerical minimization of a discretized form of the Ramakrishnan-Yussouff free energy functional.
Chaudhuri, Pinaki, Dasgupta, Chandan, Karmakar, Smarajit, Krishnamurthy, H. R., Sood, A. K.   +4 more
core   +1 more source