Results 61 to 70 of about 564,349 (198)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Universality of Phases in QCD and QCD-like Theories

, 2012
We argue that the whole or the part of the phase diagrams of QCD and QCD-like theories should be universal in the large-N_c limit through the orbifold equivalence. The whole phase diagrams, including the chiral phase transitions and the BEC-BCS crossover
A Armoni, A Barducci, A Cherman, A Cherman, AE Lawrence, AJ Leggett, AM Halasz, AM Halasz, B Klein, B Klein, B Vanderheyden, C Allton, C Lovelace, D Deryagin, D Eagles, D Espriu, D Son, D Son, D Toublan, D Toublan, D Toublan, D Weingarten, E Shuster, E Witten, EV Shuryak, G Akemann, G Akemann, G Akemann, H Abuki, H Leutwyler, I Barbour, J Erlich, J Han, J Kogut, J Kogut, J Kogut, J Verbaarschot, JC Osborn, K Fukushima, K Splittorff, L McLerran, M Bershadsky, M Bershadsky, M Kitazawa, M Schmaltz, M Ünsal, M Ünsal, MA Stephanov, MA Stephanov, Masanori Hanada, ME Peskin, MG Alford, MG Alford, MG Alford, N Yamamoto, N Yamamoto, N Yamamoto, Naoki Yamamoto, P Forcrand de, P Forcrand de, P Forcrand de, P Kovtun, P Kovtun, P Kovtun, P Nozières, R Rapp, S Hands, S Kachru, S Nussinov, SR Coleman, T Hatsuda, T Imoto, T Kanazawa, T Kanazawa, T Kojo, T Sakai, T Schafer, T Schafer, T Schafer, T Zhang   +79 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Mean-field phase diagrams of $AT_2X_2$ compounds

, 1994
Magnetic-field -- temperature phase diagrams of the axial next-nearest-neighbor Ising model are calculated within the framework of a Landau-type expansion of the free energy derived from molecular-field theory.
A. Mailhot, B. Shemirani, G.N. Hassold, J. Yeomans, L. Rebelsky, M. L. Plumer, M.F. Collins, P. Bak, W. Selke, W. Selke, W. Selke, W. Selke, Y. Yamada   +12 more
core   +2 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Nonequilibrium phase transitions and stationary state solutions of a three-dimensional random-field Ising model under a time dependent periodic external field

, 2012
Nonequilibrium behavior and dynamic phase transition properties of a kinetic Ising model under the influence of periodically oscillating random-fields have been analyzed within the framework of effective field theory (EFT) based on a decoupling ...
A. I. Larkin, Erol Vatansever, Hamza Polat, T. Kaneyoshi, Yusuf Yüksel, Ümit Akıncı   +5 more
core   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Obtaining pressure versus concentration phase diagrams in spin systems from Monte Carlo simulations

, 2008
We propose an efficient procedure for determining phase diagrams of systems that are described by spin models. It consists of combining cluster algorithms with the method proposed by Sauerwein and de Oliveira where the grand canonical potential is ...
C. E. I. Carneiro, Carlos E. Fiore, K. Binder, S. Gupta, S. Gupta, W. H. Press   +5 more
core   +1 more source