Results 51 to 60 of about 227,228 (264)
Femtometer displacement resolution with phase-insensitive Doppler sensing
Optics Letters, 2019 The measurement of extremely small displacements is of utmost importance, both for fundamental studies [1-4], and practical applications [5-7]. One way to estimate a small displacement is to measure the Doppler shift generated in light reflected off an object moving with a known periodic frequency.
Bethany J. Little +4 more
openaire +3 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
EnergiesThe distribution and mutual conversion of remaining oil during the process of oilfield development constitute an important basis for guiding the exploitation of remaining oil potential.
Chun Feng, Linghui Sun, Zhengming Yang
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
ULTRASONIC DETECTION METHOD OF blood plasma FIBRIN CLOT FORMATION MOMENT
Доклады Белорусского государственного университета информатики и радиоэлектроники, 2019 The ultrasonic method for detecting of the fibrin clot formation during the coagulation tests is propose. To start clotting cascade in research APTT and PTV tests were used. The results of investigation for detecting fibrin clot formation by changing the
A. A. Ushakova +2 more
doaj
Drone-based displacement measurement of infrastructures utilizing phase information
Nature CommunicationsDrone-based inspections provide an efficient and flexible approach to assessing aging infrastructures while prioritizing safety. Here, we present a pioneering framework that employs drone cameras for high-precision displacement measurement and achieves ...
Shien Ri +3 more
doaj +1 more source
Early‐Phase Research in Pediatric Neuro‐Oncology
Pediatric Blood &Cancer, EarlyView.
Jonathan Cunningham
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source