Results 91 to 100 of about 1,727,422 (269)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Kinetics of cathodic deposition of copper from an acid sulfate solution in the presence of organic disulfides

Конденсированные среды и межфазные границы
Objectives: In this work, we established the kinetic patterns and evaluated the main parameters of heterogeneous nucleation and growth of a new phase during the electrocrystallization of copper during cathode deposition from an acid sulfate solution in ...
Evgenia A. Ilina, Oleg A. Kozaderov, Nadezhda V. Sotskaya, Andrey D. Golovinsky, Elizaveta D. Kolbeshkina, Vladimir A. Polikarchuk   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Influence of phosphates on phase formation in alkali‐activated MgO‐Al2O3‐SiO2‐P2O5 cements

International Journal of Ceramic Engineering & Science
The impact of phosphates on phase formation in low Ca alkali‐activated materials (AAMs) is investigated using a polymer‐assisted sol‐gel process to fabricate MgO‐Al2O3‐SiO2‐P2O5 cement precursors covering a broad range of compositions activated with ...
Titus Reed, John C. Mauro, Juan Pablo Gevaudan   +2 more
doaj   +1 more source

The Effect of the Modulation Period on the Diffusion Intermixing and Magnetic Properties Behavior of Pt/Co Thin Films Induced by Ion Pre-irradiation

Фізика і хімія твердого тіла
The effects of modulation period and N+ ion pre-irradiation on the layers intermixing and magnetic properties modification of Pt/Co and Pt/Co/Pt/Co stacks were investigated.
Andrii Orlov, Roman Pedan, Ivan Kruhlov, Yurii Yavorskyi, Oleksander Dubikovskyi, Oleksander Kosulya, Andrii Bodnaruk, Igor Vladymyrskyi   +7 more
doaj   +1 more source

Phase Pattern Formation in Grain Boundaries

Physical Review Letters
In this work we derive conditions that predict the existence of two-phase periodic-pattern grain boundary structures that are stable against coarsening. While previous research has established that elastic effects can lead to phase pattern formation on crystal surfaces, the possibility of stable grain boundary structures composed of alternating grain ...
I. S. Winter, T. Frolov
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source