Results 81 to 90 of about 4,006,876 (282)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Holdup, Search and Inefficiency [PDF]

This paper investigates the holdup problem in the dynamic search market where buyers and sellers search for their trading partners and specific investments are made after match but before trade.
Shingo Ishiguro
core  

Experimental validation of the calculation of phase holdup for an oil-water two-phase vertical flow based on the measurement of pressure drops

, 2013
The performance of metering the phase holdup of an oil-water two-phase vertical flow has been investigated based on the measurement of the gravity and frictional pressure drops.
许晶禹, 李东晖, 李华, 张健, 吴应湘   +4 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Dispersed-Phase Holdup and Characteristic Velocity in a Pulsed and Nonpulsed Disk-and-Doughnut Solvent Extraction Column

, 2016
The dispersed-phase holdup and characteristic velocity, which are important hydrodynamic performance parameters for solvent extraction columns, were measured and compared to literature correlations under pulsing and nonpulsing conditions using a 75 mm ...
Zheng Li (26302), Kathryn H. Smith (1419544), Yong Wang (12837), Kathryn A. Mumford (812368), Geoffrey W. Stevens (812371)   +4 more
core   +1 more source

A two-fluid model incorporating droplet entrainment to predict pressure drop and holdup for CO2 two-phase flow in horizontal and vertical pipe

Journal of Pipeline Science and Engineering
CCUS technology is currently the best practice for reducing CO2 emissions, with pipeline transportation as the primary method for the long-distance, large-scale transport of captured CO2 to storage sites.
Changjun Li, Yupeng Liao, Wenlong Jia, Fan Yang, Jie He, Xiujuan Wang   +5 more
doaj   +1 more source

CFD study and experimental validation of low liquid-loading flow assurance in oil and gas transport: studying the effect of fluid properties and operating conditions on flow variables

Heliyon, 2020
Low liquid-loading flow frequently occurs during the transport of gas products in various industries, such as in the Oil & Gas, the Food, and the Pharmaceutical Industries.
Miguel Ballesteros Martínez, Eduardo Pereyra, Nicolás Ratkovich   +2 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source