Results 71 to 80 of about 946 (261)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Impact of Solid Particle Concentration and Liquid Circulation on Gas Holdup in Counter-Current Slurry Bubble Columns

Fluids
In this study, in a three-phase reactor with a rectangular cross-section, the effects of liquid circulation rates and solid particle concentration on gas holdup and bubble size distribution (BSD) were investigated.
Sadra Mahmoudi, Mark W. Hlawitschka
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Equivalent Dielectric Permittivity Model of Low Water Cut Oil-Water Two-Phase Flow

Cejing jishu
The capacitance method is widely used to measure the water content of oil-water two-phase flow, whether it is the surface oil-water measurement or the stratification test of the production profile in the well.
QU Jinghui, LIU Xingbin, LIU Dongmei, DENG Yuheng, LIU Dayong, YANG Yuntong   +5 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Detection of Water Holdup in Oil–Water Flows Using a Curved Microstrip Sensor with Resonance-Enhanced Response

Sensors
Accurate water holdup measurement in oil–water flows remains challenging due to flow-regime-dependent dielectric distributions and the limited sensitivity of conventional amplitude- or phase-based sensing features. This paper proposes a curved microstrip
Gaoyang Zhu, Yunjun Zhang, Junlin Feng, Xinhua Sun, Shucheng Liang, Bin Wang, Muzhi Gao   +6 more
doaj   +1 more source

Research on Liquid Holdup Measurement by Conductivity Method Based on Forced Annular Flow

Shiyou jixie, 2022
The accuracy of traditional conductivity method may be easily affected by flow pattern when it is used to measure the liquid holdup of gas-liquid two-phase flow.
Li Zhonghao, Zhang Xingkai, Liao Ruiquan, Shi Baocheng, Huang Lamei   +4 more
doaj  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The Finite Element Analysis for a Mini-Conductance Probe in Horizontal Oil-Water Two-Phase Flow

Sensors, 2016
Oil-water two-phase flow is widespread in petroleum industry processes. The study of oil-water two-phase flow in horizontal pipes and the liquid holdup measurement of oil-water two-phase flow are of great importance for the optimization of the oil ...
Weihang Kong, Lingfu Kong, Lei Li, Xingbin Liu, Ronghua Xie, Jun Li, Haitao Tang   +6 more
doaj   +1 more source