Results 71 to 80 of about 3,996,549 (283)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Holdup, Search and Inefficiency [PDF]

open access: yes
This paper investigates the holdup problem in the dynamic search market where buyers and sellers search for their trading partners and specific investments are made after match but before trade.
Shingo Ishiguro
core  

Experimental validation of the calculation of phase holdup for an oil-water two-phase vertical flow based on the measurement of pressure drops

open access: yes, 2013
The performance of metering the phase holdup of an oil-water two-phase vertical flow has been investigated based on the measurement of the gravity and frictional pressure drops.
许晶禹   +4 more
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

Dispersed-Phase Holdup and Characteristic Velocity in a Pulsed and Nonpulsed Disk-and-Doughnut Solvent Extraction Column

open access: yes, 2016
The dispersed-phase holdup and characteristic velocity, which are important hydrodynamic performance parameters for solvent extraction columns, were measured and compared to literature correlations under pulsing and nonpulsing conditions using a 75 mm ...
Zheng Li (26302)   +4 more
core   +1 more source

A two-fluid model incorporating droplet entrainment to predict pressure drop and holdup for CO2 two-phase flow in horizontal and vertical pipe

open access: yesJournal of Pipeline Science and Engineering
CCUS technology is currently the best practice for reducing CO2 emissions, with pipeline transportation as the primary method for the long-distance, large-scale transport of captured CO2 to storage sites.
Changjun Li   +5 more
doaj   +1 more source

CFD study and experimental validation of low liquid-loading flow assurance in oil and gas transport: studying the effect of fluid properties and operating conditions on flow variables

open access: yesHeliyon, 2020
Low liquid-loading flow frequently occurs during the transport of gas products in various industries, such as in the Oil & Gas, the Food, and the Pharmaceutical Industries.
Miguel Ballesteros Martínez   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

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