Results 151 to 160 of about 11,213,687 (295)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Orchestration of kaempferol nuclear translocation by phase ii metabolic enzymes and efflux transporters suppresses colorectal cancer. [PDF]

PLoS One
Zhou C, Ning Q, Jin X, Li Y, Lin Y, Lin J, Zheng J, Huang Y, Wang W, Liu Z, Lu L.   +10 more
europepmc   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Phase II trial of sodium phenylbutyrate and taurursodiol in Wolfram syndrome. [PDF]

J Clin Invest
Urano F, Marshall BA, Hurst S, Robichaux-Viehoever A, Ahmadi S, Hershey T, Van Stavern G, Cruz Bravo P, Powers Carson J, Pesko J, Fox K, Erpelding N, Bedrosian CL.   +12 more
europepmc   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Elaiussa Sebaste II- Un porto fra Oriente e Occidente

, 2003
(a cura di E.Equini Schneider)
II, EQUINI, Eugenia
core  

A Phase II Trial of Defactinib Combined with Avutometinib in Patients with Metastatic Uveal Melanoma. [PDF]

Cancers (Basel)
Seedor RS, Terai M, Koshkin S, Aplin AE, Orloff M, Sharpe-Mills E, Naccarato M, Mills A, Molinolo AA, Gutkind JS, Sato T.   +10 more
europepmc   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

A Multicentre Phase II Study of Trifluridine/Tipiracil in Recurrent/Metastatic Platinum-Resistant Nasopharyngeal Carcinomas. [PDF]

Clin Cancer Res
Low JL, Chong WQ, Hui EP, Tan TZ, Lai W, Le TBU, Sooi K, Walsh RJ, Li WY, Kong LR, Lim YC, Chan ATC, Ma B, Goh BC.   +13 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source