We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Neoadjuvant chemotherapy and bevacizumab for colorectal peritoneal metastases: clinical and translational outcomes of the phase II BEV-IP trial. [PDF]
Chia DKA +9 more
europepmc +1 more source
TQB2618 plus Penpulimab, Alone or in Combination with Chemotherapy, for Recurrent or Metastatic Nasopharyngeal Carcinoma: A Multicenter, Two-Cohort, Phase II Trial. [PDF]
Xu C +27 more
europepmc +1 more source
A phase-II randomized controlled pilot study of nicotinamide riboside supplementation in older adults with amnestic mild cognitive impairment. [PDF]
Martens CR +16 more
europepmc +1 more source
Decreased TXNRD1 is associated with resistance to tagraxofusp in blastic plasmacytoid dendritic cell neoplasms, as seen in phase II. [PDF]
Beird HC +22 more
europepmc +1 more source
Loberamisal injection for the treatment of acute ischaemic stroke: a multicentre, randomised, double-blind, placebo-controlled phase II clinical trial. [PDF]
Feng B +10 more
europepmc +1 more source

