Results 261 to 270 of about 1,964,480 (312)

Phase II angiogenesis stimulators

Expert Opinion on Investigational Drugs, 2013
Therapeutic angiogenesis is a strategy of inducing new collateral vessels and stimulating new capillaries that enhance tissue oxygen exchange in ischemic cardiovascular disorders, including acute myocardial infarction, chronic cardiac ischemia, peripheral artery disease and stroke.Over the last 10 years, promising results of early clinical trials have ...
RIBATTI, Domenico, Baiguera S.
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The future of phase II trials

Gynecologic Oncology, 2006
The CTEP database of phase II, or phase I/II clinical trials between 2000 and 2005 (exclusive for ovarian cancer), with investigational agents where CTEP holds the INDwas reviewed. Between 2000 and 2005, CTEP received 100 LOIs and 36 were approved.
John, Farley, Michael J, Birrer, Michaele C, Christian   +2 more
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Phase II

Abstract This chapter describes the importance and roles of peers in the recovery process, a method often thought of as “new” by today’s program developers, but one that was remarkable at Vermont State Hospital in the 1950s. The chapter details a report of the 5-year follow-up revealing how they did it, who was involved, and what they ...
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A Phase II Study of Mitoxantrone

Tumori Journal, 1988
Thirty pretreated patients with progressive and measurable solid tumors (24/30 patients) or myeloproliferative diseases (6/30 patients) were given mitoxantrone at the dose of 5 mg/m 2 /day in 250 ml normal saline over 30 minutes infusion for 3 consecutive days every 3 weeks.
G, Cartei, S, Mian, R, Cendron, S, Lamon, L, Clocchiatti, G, Fasola, D, Galletti, A, Sibau   +7 more
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Direct phasing in femtosecond nanocrystallography. II. Phase retrieval

Acta Crystallographica Section A Foundations and Advances, 2014
X-ray free-electron laser diffraction patterns from protein nanocrystals provide information on the diffracted amplitudes between the Bragg reflections, offering the possibility of direct phase retrieval without the use of ancillary experimental diffraction data [Spenceet al.(2011).Opt. Express,19, 2866–2873].
Chen, Joe P. J., Spence, John C. H., Millane, Rick P.   +2 more
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Multicenter Phase II Study of Spiroplatin

Oncology, 2009
Spiroplatin was investigated in a multicenter phase II study, during which the drug was given over 4 h. 64 Patients with nine different solid tumors received 141 cycles of spiroplatin at a dose of 30 mg/m2 every 3 weeks. Most important side effects included nausea, vomiting, myelosuppression, and renal toxicity. Four of 11 evaluable patients with prior
Tanis, B.C., Vermorken, J.B., ten Bokkel Huinink, W.W., van Oosterom, A.T., Splinter, T.A.W., Vendrik, K.J., Sleijfer, D.T.H., van der Burg, M.E.L., van der Putten, E., Pinedo, H.M.   +9 more
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Adding dose modifications into Phase II and Phase II/III seamless trials

Statistical Methods in Medical Research, 2019
We present a technique for adding dose modifications into seamless Phase II and Phase II/III trials featuring dose selection at an interim analysis. The method is convenient to apply and can be used either in a fully prespecified, structured way or as a response to new considerations that emerge at interim.
John Spivack, Bin Cheng, Bruce Levin
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Statistics of phase turbulence II

Physica A: Statistical Mechanics and its Applications, 2003
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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Phase II: There is no Alternative!

2011
Die „offizielle” Phase der Agenda 2010 dauert etwas mehr als 2 Jahre, bevor die rot-grune Koalition nach der verlorenen Landtagswahl 2005 in NRW von Bundeskanzler Schroder fur beendet erklart wird. Der Regierungschef versucht in der Agenda-Rede, den sozialpolitischen Kurs in auf Sachzwange verweisenden Satzen zu legitimieren.
Simon Hegelich, David Knollmann, Johanna Kuhlmann   +2 more
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Phase II Trials

2004
Early clinical investigations in oncology are distinct from therapeutics evaluations in other medical disciplines. First, the risks associated with medicines for oncologic diseases dictate that they be evaluated in cancer patients only, and not in healthy volunteers.
Keith T. Flaherty, Peter J. O’Dwyer
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