Results 71 to 80 of about 11,213,687 (295)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Dose selection in seamless phase II/III clinical trials based on efficacy and toxicity [PDF]

Seamless phase II/III clinical trials are attractive in development of new drugs because they accelerate the drug development process. Seamless phase II/III trials are carried out in two stages.
Kimani, Peter K.
core  

Identification of a 7-phase claw-pole starter-alternator for a micro-hybrid automotive application [PDF]

, 2008
This paper deals with the identification of a new high power starter-alternator system, using both: a Finite Element Method (FEM) modeling and an experimental vector control.
BOUSCAYROL, Alain, A. Bouscayrol, T. Henneron, MIPO, Jean-Claude, J.C. Mipo, DUBUS, Jean-Marc, BRUYERE, Antoine, HENNERON, Thomas, LOCMENT, Fabrice, Dubus,, J.M, E. Semail, A. Bruyere, F. Locment, SEMAIL, Eric, J.M. Dubus   +14 more
core   +1 more source

Synthesis and characterization of ethanolic extract of nutgalls of the plant Quercus infectoria silver nitrate nanoparticles incorporated chitosan based scaffold, and their in-silico study for wound healing activity

Results in Surfaces and Interfaces
Quercus infectoria is a popular medicinal plant used in many parts of the world as a treatment for various health conditions. The main components found in the galls of Quercus infectoria are tannin (50–70%) and small amounts of free Gallic acid and ...
Madhusmita Sahu, Kamakshi, Jyotirmaya Sahoo, Sudhansu Ranjan Swain, Sakshi Gupta, Nishat Fatma, Geetanjali Mehara   +6 more
doaj   +1 more source

Evaluation of the Effect of Probiotic Bacillus coagulans Unique IS2 on Mutans Streptococci and Lactobacilli Levels in Saliva and Plaque: A Double-Blind, Randomized, Placebo-Controlled Study in Children

International Journal of Dentistry, 2020
Background. Probiotic organisms are known to reduce caries causing microorganisms mutans streptococci and lactobacilli. Aim of the Study. To evaluate the effect of probiotic Bacillus coagulans Unique IS2 on mutans streptococci and lactobacilli levels in ...
M. Ratna Sudha, Jayanthi Neelamraju, M. Surendra Reddy, Manoj Kumar   +3 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

A Qualitative Evaluation of Volunteers' Experiences in a Phase I/II HIV Vaccine Trial in Tanzania. [PDF]

, 2011
Evaluating experiences of volunteers in an HIV vaccine trial will be useful for the conduct of future trials. The purpose of this study among volunteers who participated in a phase I/II HIV vaccine trial in Dar es Salaam, Tanzania was to assess what ...
Thorson, Anna, Bakari, Muhammad, Edith AM Tarimo, Fred Mhalu, Asli Kulane, Eric Sandstrom, Sandstrom Eric, Tarimo Edith AM, Anna Thorson, Kohi, Thecla W, Kulane, Asli, Bakari Muhammad, Kohi Thecla W, Mhalu, Fred, Kulane Asli, Thorson Anna, Muhammad Bakari, Sandstrom, Eric, Thecla W Kohi, Mhalu Fred, Tarimo, Edith A M   +20 more
core   +2 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

In vivo assessment, formulation, characterization and enhancing pharmacotherapy of encapsulated mini tablets for immediate release Sildenafil citrate and sustained release Bosentan

Results in Chemistry
The purpose of this study was to prepare and evaluate multiple unit mini tablets (MTs) of prolonged released (PR) bosentan (BSN) and fast release (FR) sildenafil citrate (SDC) on the basis of encapsulation method for the effective management of pulmonary
Deepak Kumar Sarangi, Chandra Sekhar Patro, Ch. Niranjan Patra, Nalini Kanta Sahoo, Nihar Ranjan Das, Komalpreet Kaur, Jahanvi Gupta   +6 more
doaj   +1 more source