Results 171 to 180 of about 319,225 (348)

Real‐Time Visualization of Isoform‐Specific RAF‐KRAS Interactions in Living Cells Using FRET‐BRET Hybrid Biosensors

open access: yesAdvanced Science, EarlyView.
Hybrid FRET–BRET biosensors were developed to monitor RAF–KRAS interactions in living cells. These sensors enable real‐time visualization of interaction dynamics, quantitative spectral analysis, and validation of mutation‐selective inhibitors, providing a versatile platform for probing KRAS regulation and therapeutic responses. ABSTRACT The RAS–RAF–MEK–
Jeong‐Min Go   +12 more
wiley   +1 more source

Multi‐Soliton Microcombs Enable Ultrafast Nanometric‐Precision Ranging and Photon‐Level Detection

open access: yesAdvanced Science, EarlyView.
Our work first demonstrates dual‐multi‐soliton ranging and confirms its multifunctional capability. The method achieves ultrafast and nanometric‐precision measurement. For practical applications, we further extend the multi‐soliton states to photon‐level ranging.
Jiawen Zhi   +10 more
wiley   +1 more source

Modification Strategies of Carbon‐Based Electrodes From Structural Regulation to Multifunctional Integration

open access: yesAdvanced Science, EarlyView.
Tracing the evolution from structural regulation to multifunctional integration, this paper systematically analyzes modification strategies for carbon‐based electrodes. It evaluates how element doping, surface functionalization, and composite material design affect the electrode performance, and offers perspectives on future applications and challenges
Yunlei Wang   +4 more
wiley   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

open access: yesAdvanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang   +7 more
wiley   +1 more source

Hidden attractors in dynamical models of phase-locked loop circuits: Limitations of simulation in MATLAB and SPICE

open access: yesCommunications in nonlinear science & numerical simulation, 2017
N. Kuznetsov   +3 more
semanticscholar   +1 more source

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