Results 211 to 220 of about 4,808,695 (292)

Targeted Mechanogenetics to Modulate Specific Deep Neural Circuits

Advanced Science, EarlyView.
This study introduces mechanogenetics, a nanobubble‐enhanced sonogenetic strategy for selective modulation of feeding‐related neural circuits in the mouse lateral hypothalamus. Mechanogenetic stimulation modulates feeding behavior through glutamatergic projections from the lateral hypothalamus to the ventral tegmental area, highlighting its potential ...
Xuandi Hou, Jianing Jing, Zhuohan Shi, Lei Sun   +3 more
wiley   +1 more source

Optimizing auditory stimulation timing in NREM sleep using brain-heart rhythms: continuous phase analysis and multidimensional phase-locking. [PDF]

Sleep
Sardooeinasab S, de Zambotti M, Baker FC, Forouzanfar M.   +3 more
europepmc   +1 more source

Ionically Counter‐Programmable Phase‐Separation of Superstable Star‐Biopolyamide Coacervates for Electrothermally‐Responsive Pseudosolid Smart Windows

Advanced Science, EarlyView.
We develop bio‐based, star‐branched polyamides from itaconic acid and cadaverine with tunable lower critical solution temperature (LCST) transitions for dynamic solar modulation. Specific metal ion coordination with pyrrolidone moieties drives precise phase transitions via calcium‐induced salting‐in and sodium‐induced salting‐out mechanisms. Formulated
Jie Liu, Xiaotian Zhu, Jinjian Hou, Jinze Du, Mohammad Asif Ali, Maiko K. Okajima, Tatsuo Kaneko   +6 more
wiley   +1 more source

Millimetre-wave comb generated by an optical microcomb. [PDF]

Nat Commun
Peters L, Cutrona A, Cooper AR, Olivieri L, Getman F, Cecconi V, Paul N, Das D, Rowley M, Chu ST, Little BE, Morandotti R, Moss DJ, Totero Gongora JS, Pasquazi A, Peccianti M.   +15 more
europepmc   +1 more source

Scaffold RNA Reengineering for a Leakage‐Suppressed CRISPR/Cas12a Cascade System Toward Precise Nucleic Acid Diagnostics

Advanced Science, EarlyView.
Schematic illustration of the CALCas system, in which a conformational switch in the 3' terminal DNA extension of scaffold RNA (3'D‐SR) drives cascade‐activatable Cas12a cleavage while suppressing leakage. ABSTRACT Amplification‐free CRISPR detection has attracted significant attention for its capacity to circumvent the intricacies of nucleic acid ...
Xingrong Li, Honghua Hu, Xinli Jiang, Xuhuai Fu, Lin Hu, Qinghua Wu, Jiatong Chai, Diangeng Li, Jinhong Guo, Zhiqiang Li, Yi Li, Yirong Li   +11 more
wiley   +1 more source

Targeting Macrophage STING O‐GlcNAcylation via Small‐Molecule Allosteric Modulation for Psoriasis Therapy

Advanced Science, EarlyView.
Paeoniflorin allosterically targets the STING cyclic dinucleotide‐binding domain, stabilizes an inactive open conformation, and disrupts STING–OGT interaction to reduce Thr229 O‐GlcNAcylation and downstream signaling. This mechanism restrains myeloid STING activation, alleviates psoriasis‐like inflammation, and is supported by analyses of patient ...
Fang‐Fang Zhuo, Cheng‐Chen Hou, Wei Wang, Ya‐Xuan Zhu, Ling Li, Li‐Juan Liu, Chuan‐Jian Lu, Peng‐Fei Tu, Yang Liu, Rui‐Zhi Zhao, Ke‐Wu Zeng   +10 more
wiley   +1 more source

Multimodal locking-enabled robust and day-scale low-repetition-rate soliton microcomb for high-precision metrology. [PDF]

Light Sci Appl
Tang J, Yang J, Yan E, Huang G, Yin K, Tian D, Lei X, Huang J, Yang M, Ding H, Yan S, Wei K, Zhu L, Wang G, Jiang T.   +14 more
europepmc   +1 more source

Personalized, EEG-controlled intermittent theta burst stimulation. [PDF]

Brain Stimul
Maldonado Osorio FA, Elhamiasl M, Gacek MK, Shankman SA, Alekseichuk I.   +4 more
europepmc   +1 more source

Global Coupling and Phase Locking in Laser Diode Arrays: A Review of Talbot Cavity Research. [PDF]

Micromachines (Basel)
Yang Y, Huang C, Chen J, Xie Y, Feng Y, Cao X, Guo Z, Tan F, Xin C, Li Z, Qu Y, Li L.   +11 more
europepmc   +1 more source

A Low-Power PLL-Less Wideband OOK Wireless Neural-Signal Transmitter for Miniaturized Neural Interfaces with In Vivo Validation in Freely Moving Mice. [PDF]

Biosensors (Basel)
Shu G, Zhang F, Yang C, Jia H, Wang X, Yin M.   +5 more
europepmc   +1 more source