Results 51 to 60 of about 165,978 (305)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Mask modeling in the low k(1) and ultrahigh NA regime: Phase and polarization effects

open access: yes, 2022
S.XXIX-XLIThis paper reviews state of the art mask modeling for optical lithography. Rigorous electromagnetic field (EMF) simulation of light diffraction from optical masks is compared to the traditional assumption of an infinitely thin mask, the so ...
Erdmann, A.
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

TanDEM-X Water Indication Mask: Generation and First Evaluation Results

open access: yes, 2012
The German SAR interferometry mission TanDEM-X performed on two TerraSAR-X satellites flying in close formation will provide a global Digital Elevation Model (DEM). A by-product is so-called the Water Indication Mask (WAM).
Roth, Achim   +5 more
core   +1 more source

Beyond the IFTA – Phase mask generation for 3D laser beam shaping, tailored temperature distributions and optical amplifiers

open access: yesJournal of the European Optical Society-Rapid Publications
The iterative Fourier transform algorithm (IFTA) is the most widely used algorithm for the generation of phase masks for laser beam shaping in the field of laser material processing. But its simplicity and efficiency also come with heavy limitations.
Hofmann Oskar   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Numerically designed phase-mask for stellar coronagraph

open access: yes, 2015
application/pdfPhase-mask coronagraph holds the ability to detect exoplanets very close to their parent star. We report a new kind of phase mask that performs the contrast ratio of more than the tenth power of 10 for a circular aperture with shades of a ...
田村, 元秀   +8 more
core   +1 more source

Phase mask coronagraphy at JPL and Palomar

open access: yesEPJ Web of Conferences, 2011
For the imaging of faint companions, phase mask coronagraphy has the dual advantages of a small inner working angle and high throughput. This paper summarizes our recent work in developing phase masks and in demonstrating their capabilities at JPL.
Serabyn E., Mawet D.
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Artificial Graphene and Related Photonic Lattices Generated With a Simple Method

open access: yesIEEE Photonics Journal, 2014
We fabricate honeycomb and related photonic lattices in a nonlinear crystal with a simple method that is based on the optical Fourier transformation through an amplitude mask (six-hole aperture) superimposed with a phase mask (three tilted glass plates).
Yuanmei Gao   +3 more
doaj   +1 more source

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