Results 41 to 50 of about 159,755 (262)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Artificial Graphene and Related Photonic Lattices Generated With a Simple Method

IEEE Photonics Journal, 2014
We fabricate honeycomb and related photonic lattices in a nonlinear crystal with a simple method that is based on the optical Fourier transformation through an amplitude mask (six-hole aperture) superimposed with a phase mask (three tilted glass plates).
Yuanmei Gao, Daohong Song, Shanshan Chu, Zhigang Chen   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A Coded Aperture Compressive Imaging Array and Its Visual Detection and Tracking Algorithms for Surveillance Systems

Sensors, 2012
In this paper, we propose an application of a compressive imaging system to the problem of wide-area video surveillance systems. A parallel coded aperture compressive imaging system is proposed to reduce the needed high resolution coded mask requirements
Hanxiao Wu, Jing Chen, Yongtian Wang
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Experimental demonstration of extended depth-of-field f/1.2 visible High Definition camera with jointly optimized phase mask and real-time digital processing [PDF]

Journal of the European Optical Society-Rapid Publications, 2015
Increasing the depth of field (DOF) of compact visible high resolution cameras while maintaining high imaging performance in the DOF range is crucial for such applications as night vision goggles or industrial inspection.
Burcklen M.-A., Diaz F., Leprêetre F., Rollin J., Delboulbé A., Lee M.-S. L., Loiseaux B., Koudoli A., Denel S., Millet P., Duhem F., Lemonnier F., Sauer H., Goudail F.   +13 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Multiplexed holographic aperture masking with liquid-crystal geometric phase masks [PDF]

Optical and Infrared Interferometry and Imaging VI, 2018
Presented at the 2018 SPIE Astronomical Telescopes + Instrumentation, Austin, Texas ...
Tuthill, Peter, Norris, Barnaby, Keller, Christoph U., Por, Emiel H., Doelman, David S., Snik, Frans, Escuti, Michael J., Wilby, Michael J.   +7 more
openaire   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Asymmetric optical cryptosystem for multiple images based on devil’s spiral Fresnel lens phase and random spiral transform in gyrator domain

Scientific Reports, 2021
An asymmetric cryptosystem is presented for encrypting multiple images in gyrator transform domains. In the encryption approach, the devil’s spiral Fresnel lens variable pure phase mask is first designed for each image band to be encrypted by using devil’
Hang Chen, Zhengjun Liu, Camel Tanougast, Walter Blondel   +3 more
doaj   +1 more source