Results 111 to 120 of about 2,767,698 (346)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Generic conditions for stable hybrid stars

open access: yes, 2013
We study the mass-radius curve of hybrid stars, assuming a single first-order phase transition between nuclear and quark matter, with a sharp interface between the quark matter core and nuclear matter mantle.
Alford, Mark G.   +2 more
core   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Superconductivity and suppressed monoclinic distortion in FeTe films enabled by higher-order epitaxy

open access: yesNature Communications
Molecular beam epitaxy enables the growth of thin film materials with novel properties and functionalities. Typically, the lattice constants of films and substrates are designed to match to minimise disorders and strains.
Yuki Sato   +13 more
doaj   +1 more source

Thermal generation of spin current in a multiferroic helimagnet

open access: yesAPL Materials, 2016
We report the experimental observation of longitudinal spin Seebeck effect in a multiferroic helimagnet Ba0.5Sr1.5Zn2Fe12O22. Temperature gradient applied normal to Ba0.5Sr1.5Zn2Fe12O22/Pt interface generates inverse spin Hall voltage of spin current ...
R. Takagi   +5 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Statistical mechanics of semi-classical colored objects [PDF]

open access: yes, 2005
A microscopic model of deconfined matter based on color interactions between semi-classical quarks is studied. A hadronization mechanism is imposed to examine the properties and the disassembly of a thermalized quark plasma and to investigate the ...
Bleicher, Marcus   +5 more
core  

Evolution of the dark matter phase-space density distributions of ΛCDM haloes [PDF]

open access: bronze, 2009
Ileana Vass   +3 more
openalex   +1 more source

Home - About - Disclaimer - Privacy