Results 111 to 120 of about 2,076,023 (303)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Experimental Demonstration of π Equivalent Phase-Shifted SBG Laser With Controlled Distributed Phase Shift

open access: yesIEEE Photonics Journal, 2019
We designed and fabricated a π equivalent phase-shifted sampled Bragg grating (SBG) semiconductor laser with a controlled distributed phase shift. The phase shift is equivalently realized with reconstruction-equivalent-chirp (REC) technique. The laser is divided into three sections with the same length.
Rulei Xiao   +6 more
openaire   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

Photon-photon correlations and entanglement in doped photonic crystals

open access: yes, 2000
We consider a photonic crystal (PC) doped with four-level atoms whose intermediate transition is coupled near-resonantly with a photonic band-gap edge.
A. Imamoğlu   +28 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Piloted simulator study of allowable time delays in large-airplane response [PDF]

open access: yes
A piloted simulation was performed to determine the permissible time delay and phase shift in the flight control system of a specific large transport-type airplane.
Bert T.?aetingas, Stephen A.dings with ran   +2 more
core   +1 more source

A Low-Loss Ku-Band Monolithic Analog Phase Shifter [PDF]

open access: yes, 1987
A GaAs monolithic Ku-band analog phase shifter integrating 90° branch line coupler with planar varactor diodes has been fabricated for the first time. A phase shift of 109° +- 3° with an insertion loss of 1.8+-0.3 dB was measured from 16 to 18 GHz. A 360°
Atwater, Harry A.   +5 more
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Research on the possibility of reducing the error in measuring the phase shift of radio signals

open access: yesInformatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska
The possibility of reducing the error in measuring the phase shift of radio signals by the orthogonal method using analogue quadrature demodulators in solving scientific and technical problems in energy, non-destructive testing, research on determining ...
Sergey Matvienko   +3 more
doaj   +1 more source

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