Results 91 to 100 of about 2,089,566 (302)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

A conditional-phase switch at the single-photon level

, 2002
We present an experimental realization of a two-photon conditional-phase switch, related to the ``$c$-$\phi $'' gate of quantum computation. This gate relies on quantum interference between photon pairs, generating entanglement between two optical modes ...
A. K. Ekert, A. Muller, A. Rauschenbeutel, A. Sørensen, Aephraim M. Steinberg, B. E. Kane, C. H. Bennett, C. H. Bennett, C. Monroe, D. Bouwmeester, D. G. Cory, D. Gottesman, D. Jaksch, E. Knill, G. K. Brennen, G. Nogues, G. T. Foster, J. A. Jones, J. D. Franson, J. I. Cirac, J. W. Noh, Jeffrey S. Lundeen, K. J. Resch, K. J. Resch, K. J. Resch, Kevin J. Resch, M. A. Nielsen, M. M. Kash, N. A. Gershenfeld, P. W. H. Pinkse, Q. A. Turchette, R. Loudon, S. E. Harris, W. T. Buttler   +33 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Excitonic effects on the two-color coherent control of interband transitions in bulk semiconductors

, 2005
Quantum interference between one- and two-photon absorption pathways allows coherent control of interband transitions in unbiased bulk semiconductors; carrier population, carrier spin polarization, photocurrent injection, and spin current injection may ...
B. I. Sturman, E. A. Manykin, E. K. Chang, E. M. Baskin, F. Bassani, G. L. Bir, H. A. Bethe, H. Haug, J. E. Sipe, J. O. Dimmock, J. R. Taylor, L. I. Schiff, M. J. Stevens, M. Shapiro, M. V. Éntin, N. B. Baranova, P. A. Roos, P. Y. Yu, R. D. R. Bhat, V. I. Shelest   +19 more
core   +1 more source

New technique for digital phase-shift control

Electronics Letters, 1969
A scheme for digital phase-shift control of a locked oscillator is proposed. If the required operating frequency is f and the locking frequency is nf, a reversal in phase of the locking frequency will shift the phase of the locked oscillator by π/n, under suitable conditions.
openaire   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

DAB minimum current stress segmented optimal control strategy based on extended phase shift control

电力工程技术
To address the issue of low transmission efficiency in dual active bridge (DAB) converters during electric vehicle charging and discharging processes, a minimum current stress optimization control strategy combining the differential extremum method with ...
Xingguo TAN, Chaomeng LI, Gaoming FENG, Xin ZHAO, Liangliang SUN   +4 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Current Stress Optimization in Buck-Boost Mode Based on New Extended Phase-Shift Dual Active Full-Bridge Converter

Shanghai Jiaotong Daxue xuebao
To reduce the current stress of dual active full-bridge converters in the buck-boost mode, a current stress optimization control strategy based on new extended-phase-shift modulation is proposed.
TAO Haijun, WANG Hongyi, YANG Naitong
doaj   +1 more source

Fast Transient Modulation for a Step Load Change in a Dual-Active-Bridge Converter with Extended-Phase-Shift Control

Energies, 2018
The manipulation of the bidirectional power in a dual-active-bridge converter relies on the adjustment of several phase-shift angles. Improper implementation of those adjustments during the transient process of a step load change may induce transient DC ...
Chuan Sun, Xiaodong Li
doaj   +1 more source