Results 81 to 90 of about 2,089,566 (302)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Progress in Atomic Fountains at LNE-SYRTE [PDF]

, 2012
We give an overview of the work done with the Laboratoire National de M\'etrologie et d'Essais-Syst\`emes de R\'ef\'erence Temps-Espace (LNE-SYRTE) fountain ensemble during the last five years.
A. Clairon, A. Clairon, A. Clairon, A. Clairon, A. Clairon, A. Clairon, A. Clairon, A. Clairon, A. Clairon, A. Clairon, A. Clairon, A. Clairon, A. Clairon, B. Chupin, B. Chupin, B. Chupin, B. Chupin, B. Chupin, B. Chupin, B. Chupin, B. Chupin, B. Chupin, B. Chupin, B. Chupin, B. Chupin, B. Chupin, D Rovera, D Rovera, D Rovera, D Rovera, D Rovera, D Rovera, D Rovera, D Rovera, D Rovera, D Rovera, D Rovera, D Rovera, D. Rovera, G. Santarelli, G. Santarelli, G. Santarelli, G. Santarelli, G. Santarelli, G. Santarelli, G. Santarelli, G. Santarelli, G. Santarelli, G. Santarelli, G. Santarelli, G. Santarelli, G. Santarelli, J. Guena, J. Guéna, J. Guéna, J. Guéna, J. Guéna, J. Guéna, J. Guéna, J. Guéna, J. Guéna, J. Guéna, J. Guéna, J. Guéna, J. Guéna, K. Gibble, K. Gibble, K. Gibble, K. Gibble, K. Gibble, K. Gibble, K. Gibble, K. Gibble, K. Gibble, K. Gibble, K. Gibble, K. Gibble, K. Gibble, M. Abgrall, M. Abgrall, M. Abgrall, M. Abgrall, M. Abgrall, M. Abgrall, M. Abgrall, M. Abgrall, M. Abgrall, M. Abgrall, M. Abgrall, M. Abgrall, M. Abgrall, M. E. Tobar, M. Lours, M. Lours, M. Lours, M. Lours, M. Lours, M. Lours, M. Lours, M. Lours, M. Lours, M. Lours, M. Lours, M. Lours, M. Lours, M.E. Tobar, M.E. Tobar, M.E. Tobar, M.E. Tobar, M.E. Tobar, M.E. Tobar, M.E. Tobar, M.E. Tobar, M.E. Tobar, M.E. Tobar, M.E. Tobar, M.E. Tobar, P. Laurent, P. Laurent, P. Laurent, P. Laurent, P. Laurent, P. Laurent, P. Laurent, P. Laurent, P. Laurent, P. Laurent, P. Laurent, P. Laurent, P. Laurent, P. Rosenbusch, P. Rosenbusch, P. Rosenbusch, P. Rosenbusch, P. Rosenbusch, P. Rosenbusch, P. Rosenbusch, P. Rosenbusch, P. Rosenbusch, P. Rosenbusch, P. Rosenbusch, P. Rosenbusch, P. Rosenbusch, R. Li, R. Li, R. Li, R. Li, R. Li, R. Li, R. Li, R. Li, R. Li, R. Li, R. Li, R. Li, Ruoxin Li, , S. Bize, S. Bize, S. Bize, S. Bize, S. Bize, S. Bize, S. Bize, S. Bize, S. Bize, S. Bize, S. Bize, S. Bize, S. Bize   +168 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Deterministic and cascadable conditional phase gate for photonic qubits

, 2012
Previous analyses of conditional \phi-phase gates for photonic qubits that treat cross-phase modulation (XPM) in a causal, multimode, quantum field setting suggest that a large (~\pi rad) nonlinear phase shift is always accompanied by fidelity-degrading ...
Chuang, Isaac L., Chudzicki, Christopher, Shapiro, Jeffrey H.   +2 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Effective control of the error in a direct measurement of core-loss power [PDF]

, 1995
Accuracy of a direct measurement of core-loss power is severely limited in many applications by the extra phase shift between the measured voltage and current.
Tan, F. Dong, Vollin, Jeff L., Ćuk, Slobodan   +2 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source