Results 191 to 200 of about 178,783 (273)

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Exploiting hidden singularity on the surface of the Poincaré sphere. [PDF]

Nat Commun
Li J, Jana A, Yuan Y, Zhang K, Burokur SN, Genevet P.   +5 more
europepmc   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source

Quantum ghost imaging of transparent birefringent patterns with phase singularities. [PDF]

Sci Rep
Devrari V, Singh M.
europepmc   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Quasi-random square gabor spiral zone plates for high-order diffraction suppression and multi-functional optical vortex generation. [PDF]

PLoS One
Hu H, Ding J, Wu W, Xu H, Shi G, Li H.
europepmc   +1 more source

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan, Marco Pitteri, Michael Foster, Sara Collorone, Sara Salama, Elisa Colato, Ferran Prados, Baris Kanber, Marios Yiannakas, Claudia A. M. Gandini Wheeler‐Kingshott, Indran Davagnanam, Frederik Barkhof, Declan Chard, Olga Ciccarelli, Ahmed Toosy   +14 more
wiley   +1 more source

Scalable optical vortex arrays enabled by the decomposition of Laguerre-Gaussian beams into three Hermite-Gaussian modes and multibeam interference. [PDF]

Light Sci Appl
Nakata Y, Miyanaga N, Kosaka Y, Yoshida M.   +3 more
europepmc   +1 more source

Remarkable Recovery After Delayed High‐Dose Methylprednisolone in a Rare Case of Penetrating Spinal Cord Injury

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Traumatic spinal cord injury (TSCI) caused by sharp‐force penetration is exceptionally rare, and the use of high‐dose methylprednisolone (MP) remains highly controversial, especially beyond the conventional 8‐h treatment window. This case report describes a 30‐year‐old male with acute incomplete TSCI following a knife stab wound to the right ...
Honghong Wang, Shuang Liu, Jiale Wang, Kaiyang Xue, Shenwei Li, Zhongheng Du   +5 more
wiley   +1 more source

Roadmap on singular optics and its applications. [PDF]

Appl Phys B
Balasubramaniam GM, Allam SR, Anand V, Ansari MH, Arockiaraj FG, Arnon S, Badavath PS, Baliyan M, Bouchal P, Bouchal Z, Choudhary S, Dorrah AH, Duan Y, Everts K, Forbes A, Foreman MR, Gailevičius D, Gautam A, Gbur G, Gopinath S, Joshi N, Juodkazis S, Korotkova O, Kukli K, Kupferman J, Kumar P, Kumar R, Kumar V, Manavalan G, Mehra A, Nishchal NK, Omatsu T, Peters C, Reddy ANK, Reddy SG, Rodríguez-Fajardo V, Rosales-Guzmán C, Rosen J, Sarita, Shikder A, Singh RK, Su X, Tamm A, Velagala G, Viewegh P, Vilardell EP, Willner AE, Xavier API, Yadav A, Zhou H.   +49 more
europepmc   +1 more source