Results 221 to 230 of about 2,386,664 (289)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Unusual plastic strain-induced phase transformation phenomena in silicon. [PDF]

Nat Commun
Yesudhas S, Levitas VI, Lin F, Pandey KK, Smith JS.   +4 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Surface Iodide Defects Control the Kinetics of the CsPbI₃ Perovskite Phase Transformation. [PDF]

ACS Energy Lett
Wylie ZR, Al Katrib M, Campagna R, Outen JE, Smith S, Ruffolo P, Bérenguier B, Bouttemy M, Schulz P, Christians JA.   +9 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Machine learning-driven molecular dynamics unveils a bulk phase transformation driving ammonia synthesis on barium hydride. [PDF]

Nat Commun
Tosello Gardini A, Raucci U, Parrinello M.   +2 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Effect of radiation-induced vacancy saturation on the first-order phase transformation in nanoparticles: insights from a model. [PDF]

Beilstein J Nanotechnol
Shirinyan A, Bilogorodskyy Y.
europepmc   +1 more source

Author Correction: Layer-by-layer phase transformation in Ti₃O₅ revealed by machine-learning molecular dynamics simulations. [PDF]

Nat Commun
Liu M, Wang J, Hu J, Liu P, Niu H, Yan X, Li J, Yan H, Yang B, Sun Y, Chen C, Kresse G, Zuo L, Chen XQ.   +13 more
europepmc   +1 more source

The effect of Zn doping on the structure, phase transformation and electric properties of 0.5BZT-0.5BCT materials. [PDF]

Heliyon
Huang L.
europepmc   +1 more source