Results 171 to 180 of about 11,211,974 (397)

Detection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR

open access: yesMolecular Oncology, EarlyView.
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou   +11 more
wiley   +1 more source

Phase Transition in Ant Colony Optimization

open access: yesPhysics
Ant colony optimization (ACO) is a stochastic optimization algorithm inspired by the foraging behavior of ants. We investigate a simplified computational model of ACO, wherein ants sequentially engage in binary decision-making tasks, leaving pheromone ...
Shintaro Mori   +3 more
doaj   +1 more source

Phase Transitions in the Early Universe: Impacts on BBN and CMB Observables [PDF]

open access: yesarXiv
We explore the effects of low-scale cosmological first-order phase transitions on Big Bang Nucleosynthesis (BBN) and Cosmic Microwave Background (CMB) anisotropy and distortion. We examine two scenarios: the distribution of the phase-transition energy in the cosmic background and the phase transition as an additional source of energy injection.
arxiv  

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu   +7 more
wiley   +1 more source

Baryogenesis via leptonic CP-violating phase transition

open access: yesPhysics Letters B, 2018
We propose a new mechanism to generate a lepton asymmetry based on the vacuum CP-violating phase transition (CPPT). This approach differs from classical thermal leptogenesis as a specific seesaw model, and its UV completion, need not be specified.
Silvia Pascoli   +2 more
doaj  

Multifunctional Phase-Transition Nanoparticles for Effective Targeted Sonodynamic-Gene Therapy Against Thyroid Papillary Carcinoma

open access: yesInternational Journal of Nanomedicine, 2023
Shihui Guan, Dengke Teng, Hui Wang,* Qimeihui Wang,* Xi Zhen, Guoqing Sui, Yang Wang, Lingyu Zhu, Yuanqiang Lin, Dan Jiao, Feng Guo Department of Ultrasound, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, 130033 ...
Guan S   +10 more
doaj  

Topological Theory of Classical and Quantum Phase Transition [PDF]

open access: yesarXiv, 2005
We presented the topological current of Ehrenfest definition of phase transition. It is shown that different topology of the configuration space corresponds to different phase transition, it is marked by the Euler number of the interaction potential.
arxiv  

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

open access: yesMolecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock   +10 more
wiley   +1 more source

Phase transitions of ε-HNIW in compound systems

open access: yesAIP Advances, 2016
The heat-induced phase transitions of ε-HNIW, both neat and coated with various additives used in plastic bonded explosives, were investigated using powder X-ray diffraction and differential scanning calorimetry.
Jing-yuan Zhang   +3 more
doaj   +1 more source

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