Evaluating artificial intelligence in medicine: phases of clinical research. [PDF]
JAMIA Open, 2020 Abstract Increased scrutiny of artificial intelligence (AI) applications in healthcare highlights the need for real-world evaluations for effectiveness and unintended consequences. The complexity of healthcare, compounded by the user- and context-dependent nature of AI applications, calls for a multifaceted approach beyond traditional in
Park Y +5 more
europepmc +5 more sources
Unique intrahepatic transcriptomics profiles discriminate the clinical phases of a chronic HBV infection. [PDF]
PLoS ONE, 2017 Chronic hepatitis B is a highly heterogeneous liver disease characterized by phases with fluctuations in viral replication and progressive liver damage in some, but not all infected individuals.
Jun Hou +8 more
doaj +3 more sources
A framework for clinical and translational research in the era of rigor and reproducibility
Journal of Clinical and Translational Science, 2021 Introduction: Rigor and reproducibility are two important cornerstones of medical and scientific advancement. Clinical and translational research (CTR) contains four phases (T1–T4), involving the translation of basic research to humans, then to clinical ...
Chris Wichman, Lynette M. Smith, Fang Yu
doaj +2 more sources
Quantifying the use of connected digital products in clinical research
npj Digital Medicine, 2020 Over recent years, the adoption of connected technologies has grown dramatically, with potential for improving health care delivery, research, and patient experience.
Caroline Marra +3 more
doaj +2 more sources
VetCompass Australia: A National Big Data Collection System for Veterinary Science [PDF]
Animals, 2017 VetCompass Australia is veterinary medical records-based research coordinated with the global VetCompass endeavor to maximize its quality and effectiveness for Australian companion animals (cats, dogs, and horses).
Paul McGreevy +18 more
doaj +8 more sources
Gendered Logics of Biomedical Research: Women in U.S. Phase I Clinical Trials [PDF]
Social Problems, 2020 Abstract Despite the importance of including diverse populations in biomedical research, women remain underrepresented as healthy volunteers in the testing of investigational drugs in Phase I trials. Contributing significantly to this are restrictions that pharmaceutical companies place on the participation of women of so-called ...
Marci D. Cottingham, Jill A. Fisher
openalex +4 more sources
Where is clinical research for radiotherapy going? Cross-sectional comparison of past and contemporary phase III clinical trials [PDF]
Radiation Oncology, 2020 Abstract Purpose The features of past and contemporary phase III clinical trials for radiotherapy were reviewed to activate future clinical trials and to advise on actual clinical practice. Methods and materials The phase III clinical trials for radiotherapy were searched in
Sunmin Park, Chai Hong Rim, Won Sup Yoon
openalex +5 more sources
Clinical research on new drugs (Phase I). Profile of scientific publications: data from the pre-clinical phase and bioethical aspects [PDF]
Acta Cirurgica Brasileira, 2008 PURPOSE: To trace a profile of scientific publications, phase I, in order to know whether or not they show pre-clinical phase data, emphasizing bioethical aspects. METHODS: Sixty-one scientific articles, published in 2007, involving research in human beings using new drugs, medicines and vaccines during phase I were analysed.
Vanessa de Souza Brick +2 more
openalex +9 more sources
Asia‐inclusive global development of pevonedistat: Clinical pharmacology and translational research enabling a phase 3 multiregional clinical trial [PDF]
Clinical and Translational Science, 2021 AbstractThe investigational NEDD8‐activating enzyme inhibitor pevonedistat is being evaluated in combination with azacitidine versus single‐agent azacitidine in patients with higher‐risk myelodysplastic syndrome (higher‐risk MDS), higher‐risk chronic myelomonocytic leukemia (higher‐risk CMML), or low‐blast acute myeloid leukemia (AML) in a Phase 3 ...
Xiaofei Zhou +13 more
openalex +5 more sources
Phase I and Phase II Therapies for Acute Ischemic Stroke: An Update on Currently Studied Drugs in Clinical Research [PDF]
BioMed Research International, 2017 Acute ischemic stroke is a devastating cause of death and disability, consequences of which depend on the time from ischemia onset to treatment, the affected brain region, and its size. The main targets of ischemic stroke therapy aim to restore tissue perfusion in the ischemic penumbra in order to decrease the total infarct area by maintaining blood ...
Cesar Reis +6 more
openaire +5 more sources