Evaluating artificial intelligence in medicine: phases of clinical research. [PDF]
JAMIA Open, 2020 Abstract Increased scrutiny of artificial intelligence (AI) applications in healthcare highlights the need for real-world evaluations for effectiveness and unintended consequences. The complexity of healthcare, compounded by the user- and context-dependent nature of AI applications, calls for a multifaceted approach beyond traditional in
Park Y +5 more
europepmc +5 more sources
Asia‐inclusive global development of pevonedistat: Clinical pharmacology and translational research enabling a phase 3 multiregional clinical trial [PDF]
Clinical and Translational Science, 2021 AbstractThe investigational NEDD8‐activating enzyme inhibitor pevonedistat is being evaluated in combination with azacitidine versus single‐agent azacitidine in patients with higher‐risk myelodysplastic syndrome (higher‐risk MDS), higher‐risk chronic myelomonocytic leukemia (higher‐risk CMML), or low‐blast acute myeloid leukemia (AML) in a Phase 3 ...
Xiaofei Zhou +13 more
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Quantifying the use of connected digital products in clinical research
npj Digital Medicine, 2020 Over recent years, the adoption of connected technologies has grown dramatically, with potential for improving health care delivery, research, and patient experience.
Caroline Marra +3 more
doaj +2 more sources
A framework for clinical and translational research in the era of rigor and reproducibility
Journal of Clinical and Translational Science, 2021 Introduction: Rigor and reproducibility are two important cornerstones of medical and scientific advancement. Clinical and translational research (CTR) contains four phases (T1–T4), involving the translation of basic research to humans, then to clinical ...
Chris Wichman, Lynette M. Smith, Fang Yu
doaj +2 more sources
Where is clinical research for radiotherapy going? Cross-sectional comparison of past and contemporary phase III clinical trials [PDF]
Radiation Oncology, 2020 Abstract Purpose The features of past and contemporary phase III clinical trials for radiotherapy were reviewed to activate future clinical trials and to advise on actual clinical practice. Methods and materials The phase III clinical trials for radiotherapy were searched in
Sunmin Park, Chai Hong Rim, Won Sup Yoon
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Gendered Logics of Biomedical Research: Women in U.S. Phase I Clinical Trials [PDF]
Social Problems, 2020 Abstract Despite the importance of including diverse populations in biomedical research, women remain underrepresented as healthy volunteers in the testing of investigational drugs in Phase I trials. Contributing significantly to this are restrictions that pharmaceutical companies place on the participation of women of so-called ...
Marci D. Cottingham, Jill A. Fisher
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Clinical research on new drugs (Phase I). Profile of scientific publications: data from the pre-clinical phase and bioethical aspects [PDF]
Acta Cirurgica Brasileira, 2008 PURPOSE: To trace a profile of scientific publications, phase I, in order to know whether or not they show pre-clinical phase data, emphasizing bioethical aspects. METHODS: Sixty-one scientific articles, published in 2007, involving research in human beings using new drugs, medicines and vaccines during phase I were analysed.
Vanessa de Souza Brick +2 more
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Prevalence, trends, and characteristics of trials investigating local therapy in contemporary phase 3 clinical cancer research [PDF]
Cancer, 2023 AbstractBackgroundAlthough most patients with cancer are treated with local therapy (LT), the proportion of late‐phase clinical trials investigating local therapeutic interventions is unknown. The purpose of this study was to determine the proportion, characteristics, and trends of phase 3 cancer clinical trials assessing the therapeutic value of LT ...
Alexander D. Sherry +13 more
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Design-phase prediction of potential cancer clinical trial accrual success using a research data mart [PDF]
Journal of the American Medical Informatics Association, 2013 Many cancer interventional clinical trials are not completed because the required number of eligible patients are not enrolled.To assess the value of using a research data mart (RDM) during the design of cancer clinical trials as a predictor of potential patient accrual, so that less trials fail to meet enrollment requirements.The eligibility criteria ...
Jack London +3 more
openalex +3 more sources
The influence of the menstrual cycle on muscle injuries - a systematic review and meta-analysis [PDF]
Scientific ReportsThis systematic review and meta-analysis examined the relationship between menstrual cycle phases and the incidence of muscle injuries in female team sport athletes, following PRISMA 2020 and PERSiST guidelines.
Yannik Guthardt +2 more
doaj +2 more sources