Results 11 to 20 of about 621,270 (230)

A retrospective analysis of phase I and phase I/II investigator-initiated clinical trials conducted by the Swiss Group for Clinical Cancer Research (SAKK)

ESMO Open
Background Phase I trials represent the initial step in the clinical evaluation of a new drug or new drug combination. The main characteristics and designs of phase I trials have changed throughout the years to better support the development of drugs with different specificities compared with traditional chemotherapy.Patients And Methods We reviewed ...
Kira‐Lee Koster, Ilaria Colombo, Stefanie Hayoz, Klaus Eckhardt, A. Rojas Mora, Dagmar Hess, Christian Britschgi, Simon Haefliger, Martina Imbimbo, Francesco Bertoni, Krisztián Homicskó, Roger von Moos, Cristiana Sessa, Markus Joerger, Anastasios Stathis   +14 more
openalex   +2 more sources

Outcomes of Research Biopsies in Phase I Clinical Trials: The MD Anderson Cancer Center Experience [PDF]

The Oncologist, 2011
Abstract Background. Research biopsies are crucial for exploring the impact of novel agents on putative targets. The current study assesses the safety and success rate associated with performing such biopsies. Methods.
Hazem El‐Osta, David S. Hong, Jennifer J. Wheler, Siqing Fu, Aung Naing, Gerald S. Falchook, Marshall E. Hicks, Sijin Wen, Apostolia M. Tsimberidou, Razelle Kurzrock   +9 more
openalex   +4 more sources

Phases of methodological research in biostatistics—Building the evidence base for new methods [PDF]

Biometrical journal. Biometrische Zeitschrift, 2022
Although new biostatistical methods are published at a very high rate, many of these developments are not trustworthy enough to be adopted by the scientific community.
Georg Heinze, A. Boulesteix, M. Kammer, T. Morris, Ian R. White   +4 more
semanticscholar   +1 more source

Phase II Clinical Research Design in Cardiology [PDF]

Circulation, 2013
Joshua M. Hare, Roberto Bolli, John P. Cooke, David J. Gordon, Timothy D. Henry, Emerson C. Perin, Keith L. March, Michael P. Murphy, Carl J. Pepine, Robert D. Simari, Sonia I. Skarlatos, Jay H. Traverse, James T. Willerson, Anita Szady, Doris A. Taylor, Rachel W. Vojvodic, Phillip C. Yang, Lemuel A. Moyé   +17 more
openalex   +2 more sources

Experiences and perceptions of clinical research participation at an academic medical center [PDF]

Journal of Health and Social Sciences, 2023
Introduction: The purpose of this study was to capture experiences and explore perceptions of clinical faculty research participation at an academic medical center in the southeastern United States to allow leadership to train, recruit, and retain ...
Joshua T. CLARK, Angela BURRELL, Amber ARNOLD, Travis W. SCHMITZ, Lei ZHANG, Daniel W. JONES, Richard L. SUMMERS, Whitney BONDURANT, Vinayak K. NAHAR   +8 more
doaj   +1 more source

Designing an In Vivo Preclinical Research Study

Surgeries, 2023
During the preclinical research process, multiple factors can be difficult to implement without the careful consideration and planning of each step. As research has become more advanced with the use of increasingly complex technology, animal models have ...
Angel Moctezuma-Ramirez, David Dworaczyk, Julia Whitehorn, Ke Li, Cristiano de Oliveira Cardoso, Abdelmotagaly Elgalad   +5 more
doaj   +1 more source

Phases of clinical trials: a review

Asian Journal of Hospital Pharmacy, 2022
A Clinical trial is a research study in human volunteers to answer specific health questions. Carefully conducted clinical trials are fastest and safest way to find treatment that work in people and way to improve health. Investigational trials determine
Venkata Reddy Samala, K. C, Venkatesh P
semanticscholar   +1 more source

Could a phase model help to improve translational animal research?

Animal Models and Experimental Medicine, 2022
Background Animal models are widely applied in medical research for different purposes. In particular, results from translational experiments may be used for subsequent clinical development.
Benjamin Mayer, Jan Tuckermann, Rainer Muche   +2 more
doaj   +1 more source

Erythropoiesis Differences in Various Clinical Phases of Dengue Fever using Immature Reticulocyte Fraction Parameter

International Journal of Integrated Health Sciences, 2021
Objective: To determine the mechanism of erythropoiesis that led to anemia using the Immature Reticulocyte Fraction (IRF) parameter in various clinical phases of dengue fever.
Amaylia Oehadian, Putri Vidyaniati, Jeffery Malachi Candra, Uun Sumardi, Evan Susandi, Bachti Alisjahbana   +5 more
doaj   +1 more source

The Frequency of Emotions and Emotion Variability in Self-regulated Learning: What Matters to Task Performance?

Frontline Learning Research, 2021
Emotion variability and its relationship to performance is an underexplored area of research both inside and outside the realm of medical education.
Shan Li, Juan Zheng, Susanne P. Lajoie
doaj   +1 more source