Results 11 to 20 of about 1,190,674 (269)
From research to practice: clinical phases for drug development
Revista Alergia México, 2019 Clinical trials become very relevant in the development of new drugs when their pharmacokinetics, pharmacodynamics, efficiency, safety and possible adverse effects are being assessed.
Jessie Nallely Zurita-Cruz +2 more
doaj +3 more sources
Statistical controversies in clinical research: requiem for the 3 + 3 design for phase I trials [PDF]
Annals of Oncology, 2015 More than 95% of published phase I trials have used the 3 + 3 design to identify the dose to be recommended for phase II trials. However, the statistical community agrees on the limitations of the 3 + 3 design compared with model-based approaches. Moreover, the mechanisms of action of targeted agents strongly challenge the hypothesis that the maximum ...
Xavier Paolettí +2 more
openalex +4 more sources
Qualitative analysis of clinical research coordinators' role in phase I cancer clinical trials
Contemporary Clinical Trials Communications, 2017 Clinical research coordinators play a pivotal role in phase I cancer clinical trials.We clarified the care coordination and practice for patients provided by clinical research coordinators in phase I cancer clinical trials in Japan and elucidated clinical research coordinators' perspective on patients' expectations and understanding of these trials ...
Noriko Fujiwara +6 more
openalex +5 more sources
Oncology Reviews, 2013 The Personalized Medicine approach in oncology is a direct result of an improved understanding of complex tumor biology and advances in diagnostic technologies. In recent years, there has been an increased demand for archival and fresh tumor analysis in early clinical trials to foster proof-of-concept biomarker development, to understand resistance ...
Matilde Saggese +4 more
openalex +5 more sources
Experiences and perceptions of clinical research participation at an academic medical center [PDF]
Journal of Health and Social Sciences, 2023 Introduction: The purpose of this study was to capture experiences and explore perceptions of clinical faculty research participation at an academic medical center in the southeastern United States to allow leadership to train, recruit, and retain ...
Joshua T. CLARK +8 more
doaj +1 more source
Designing an In Vivo Preclinical Research Study
Surgeries, 2023 During the preclinical research process, multiple factors can be difficult to implement without the careful consideration and planning of each step. As research has become more advanced with the use of increasingly complex technology, animal models have ...
Angel Moctezuma-Ramirez +5 more
doaj +1 more source
Phases of clinical trials: a review
Asian Journal of Hospital Pharmacy, 2022 A Clinical trial is a research study in human volunteers to answer specific health questions. Carefully conducted clinical trials are fastest and safest way to find treatment that work in people and way to improve health. Investigational trials determine
Venkata Reddy Samala, K. C, Venkatesh P
semanticscholar +1 more source
Could a phase model help to improve translational animal research?
Animal Models and Experimental Medicine, 2022 Background Animal models are widely applied in medical research for different purposes. In particular, results from translational experiments may be used for subsequent clinical development.
Benjamin Mayer +2 more
doaj +1 more source
International Journal of Integrated Health Sciences, 2021 Objective: To determine the mechanism of erythropoiesis that led to anemia using the Immature Reticulocyte Fraction (IRF) parameter in various clinical phases of dengue fever.
Amaylia Oehadian +5 more
doaj +1 more source