Results 21 to 30 of about 1,190,674 (269)

Developing a pressure ulcer risk factor minimum data set and risk assessment framework [PDF]

open access: yes, 2014
AIM: To agree a draft pressure ulcer risk factor Minimum Data Set to underpin the development of a new evidenced-based Risk Assessment Framework.BACKGROUND: A recent systematic review identified the need for a pressure ulcer risk factor Minimum Data Set ...
Bader, Dan L   +19 more
core   +10 more sources

The Frequency of Emotions and Emotion Variability in Self-regulated Learning: What Matters to Task Performance?

open access: yesFrontline Learning Research, 2021
Emotion variability and its relationship to performance is an underexplored area of research both inside and outside the realm of medical education.
Shan Li, Juan Zheng, Susanne P. Lajoie
doaj   +1 more source

Exploiting a Research Underclass in Phase 1 Clinical Trials [PDF]

open access: yesNew England Journal of Medicine, 2008
Paying study subjects is not a new practice, but neither is it uncontroversial. Dr. Carl Elliott and Roberto Abadie ask, is it ethically problematic to pay poor people to test the safety of new drugs?
Elliott, Carl, Abadie, Roberto
openaire   +3 more sources

Compliance in Early-Phase Cancer Clinical Trials Research [PDF]

open access: yesThe Oncologist, 2013
Abstract Regulations and ethical principles require that investigators seek consent and that patients participate in experimental studies only under circumstances that minimize the possibility of undue pressure and/or enticements.
David J. Stewart, Razelle Kurzrock
openaire   +3 more sources

Application of MIDD in Clinical Research of Antitumor Drugs

open access: yesChinese Journal of Lung Cancer, 2022
The antitumor drug has become one of the focused areas in new drug research and development. Their clinical research generally consumes a long period of time, with high cost and high risk.
Mengyang YU, Hongyun WANG
doaj   +1 more source

Assessment of effects of moon phases on hospital outpatient visits: An observational national study

open access: yesAIMS Public Health, 2023
Objectives: A vast amount of literature has been conducted for investigating the association of different lunar phases with human health; and it has mixed reviews for association and non-association of diseases with lunar phases. This study investigates
Mohy Uddin   +6 more
doaj   +1 more source

To what degree are orphan drugs patient-centered? A review of the current state of clinical research in rare diseases

open access: yesOrphanet Journal of Rare Diseases, 2020
Background Over the past 30 years, the healthcare industry has increasingly turned its attention to rare diseases. Regulators have emphasized the need for clinical research in this area to be patient-centered.
S. Lanar   +4 more
semanticscholar   +1 more source

Post-COVID-19 Anosmia and Therapies: Stay Tuned for New Drugs to Sniff Out

open access: yesDiseases, 2023
Background: Anosmia is defined as the complete absence of olfactory function, which can be caused by a variety of causes, with upper respiratory tract infections being among the most frequent causes.
Gabriele Riccardi   +5 more
doaj   +1 more source

Guidance on interim analysis methods in clinical trials

open access: yesJournal of Clinical and Translational Science, 2023
Interim analyses in clinical trials can take on a multitude of forms. They are often used to guide Data and Safety Monitoring Board (DSMB) recommendations to study teams regarding recruitment targets for large, later-phase clinical trials.
J. Ciolino, A. Kaizer, L. B. Bonner
semanticscholar   +1 more source

P-hacking in clinical trials and how incentives shape the distribution of results across phases [PDF]

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2019
Significance Statistical significance in clinical trials is a key prerequisite for marketing approval of new drugs. The large economic payoffs at stake might undermine investigators’ ethical obligations and incentivize manipulation of results. This study
J. Adda, C. Decker, M. Ottaviani
semanticscholar   +1 more source

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