Results 21 to 30 of about 40,175 (267)
Rapid experimental SAD phasing and hot-spot identification with halogenated fragments
IUCrJ, 2016 Through X-ray crystallographic fragment screening, 4-bromopyrazole was discovered to be a `magic bullet' that is capable of binding at many of the ligand `hot spots' found in HIV-1 reverse transcriptase (RT).
Joseph D. Bauman +2 more
doaj +1 more source
A general method for directly phasing diffraction data from high-solvent-content protein crystals
IUCrJ, 2022 A procedure is described for direct phase determination in protein crystallography, applicable to crystals with high solvent content. The procedure requires only the diffraction data and an estimate of the solvent content as input.
Richard Lawrence Kingston +1 more
doaj +1 more source
Development and research of generalized computer model of electric drive with pulse-phase control of angular velocity [PDF]
Омский научный вестник, 2019 The article presents a generalized computer model of electric drive with pulse-phase control of angular velocity. The model is created on the basis of the pulsed frequency-phase discriminator model with additional functionality that allows to ...
A. V. Bubnov +2 more
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Complete genome phasing of family quartet by combination of genetic, physical and population-based phasing analysis. [PDF]
PLoS ONE, 2013 Phased genome maps are important to understand genetic and epigenetic regulation and disease mechanisms, particularly parental imprinting defects. Phasing is also critical to assess the functional consequences of genetic variants, and to allow precise ...
Julien Lajugie +5 more
doaj +1 more source
IUCrJHighly accurate protein structure prediction can generate accurate models of protein and protein–protein complexes in X-ray crystallography. However, the question of how to make more effective use of predicted models for completing structure analysis ...
Zengru Li, Haifu Fan, Wei Ding
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Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2
Nature Communications, 2018 Neurofibromin 2 (NF2) is a tumour suppressor that inhibits cell growth. Here the authors combine functional, biochemical, and structural studies and show that lipid-bound NF2 adopts an open conformation and that NF2 lipid binding is required for ...
Krishna Chinthalapudi +7 more
doaj +1 more source
Accurate genome-wide phasing from IBD data
BMC Bioinformatics, 2022 As genotype databases increase in size, so too do the number of detectable segments of identity by descent (IBD): segments of the genome where two individuals share an identical copy of one of their two parental haplotypes, due to shared ancestry.
Keith Noto, Luong Ruiz
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Exome-wide evidence of compound heterozygous effects across common phenotypes in the UK Biobank
Cell GenomicsSummary: The phenotypic impact of compound heterozygous (CH) variation has not been investigated at the population scale. We phased rare variants (MAF ∼0.001%) in the UK Biobank (UKBB) exome-sequencing data to characterize recessive effects in 175,587 ...
Frederik H. Lassen +10 more
doaj +1 more source
Phase Transitions in Phase Retrieval [PDF]
, 2015 Consider a scenario in which an unknown signal is transformed by a known linear operator, and then the pointwise absolute value of the unknown output function is reported. This scenario appears in several applications, and the goal is to recover the unknown signal -- this is called phase retrieval. Phase retrieval has been a popular subject of research
openaire +2 more sources
Quaternion modeling of the helical path for analysis of the shape of the DNA molecule
Вавиловский журнал генетики и селекции, 2018 The threedimensional shape of a DNA molecule is a key property influencing its functional specificity and the nature of its molecular interactions. The characteristic shape into which a DNA molecule folds under certain conditions is a manifestation of ...
A. F. Muterko
doaj +1 more source