<i>Crithidia fasciculata</i> Shows Non-Pathogenic Behavior in Leishmania Co-Infection Related to Temperature Stress, In Vitro and In Vivo Infections, and Amphotericin B Susceptibility. [PDF]
Santos JFBD +10 more
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Recent Advances in Alkaloids from Papaveraceae in China: Structural Characteristics and Pharmacological Effects. [PDF]
Zhang M, Yang J, Sun Y, Kuang H.
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Rh(III)-Catalyzed Regioselective [4 + 2] Annulation of 2-Benzyl-2H-indazole-6-carboxylic Acids with Ynamides to Access Indazole-Fused Pyrans. [PDF]
Hsieh HS +4 more
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A Bifunctional Protease Cleaves the Leader Peptide in the Biosynthesis of Class I Microviridins. [PDF]
Brüssow N +7 more
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A cell surface transporter mediates phenanthridine resistance in African trypanosomes
Steketee PC +11 more
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An efficient acylation/cyclization reaction of 6-acyl phenanthridines with oxime esters using photoredox catalysis has been developed. This radical acyl transfer strategy enables a facile access to acyl-substituted phenanthridines with good yield and ...
Yilin Liu
exaly +2 more sources
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Antimalarial benzo[c]phenanthridines
Bioorganic & Medicinal Chemistry Letters, 2005Analogues of the antimalarial alkaloid nitidine have been prepared with high potency against both chloroquine-sensitive and -resistant strains of Plasmodium falciparum in vitro. Simple modifications, using an established synthetic route, resulted in an analogue with IC(50) below 5ng/mL against a chloroquine-sensitive strain of P. falciparum.
James M, Nyangulu +7 more
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Synthesis of Phenanthridine Derivatives via Photolysis
The Journal of Organic Chemistry, 2011An improved photochemical method for producing the prolifically bioactive phenanthridine system is reported. A wide variety of derivatives were obtained in two steps in yields ranging from 31 to 95%.
Linsenmeier, A. +2 more
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Acridities and phenanthridines
2020The acridine and phenanthridine chromophores both contain a central six-membered aromatic nitrogen heterocycle, with benzo rings fused onto each side. Although sulfonated and hydroxylated acridines have been synthesized, none are used as stains. The hydrophilic/lipophilic properties of the dyes under usage conditions are varied.
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