Results 51 to 60 of about 1,676 (183)
MedComm, Volume 7, Issue 4, April 2026.This review article provides a comprehensive exploration of the synergistic integration of molecular dynamics (MD) simulations and metal–organic frameworks (MOFs) to advance the design and optimization of nanoscale drug delivery systems (DDSs). We believe this work will be of significant interest to researchers in nanomedicine, computational biology ...
Jiahao Xu +11 more
wiley +1 more source
Dual Targeting of DNA and EGFR by ZYH005 Induces DNA Damage and Mitotic Catastrophe in Glioblastoma
MedComm, Volume 7, Issue 4, April 2026.ZYH005 exerts potent anti‐glioblastoma activity through a dual mechanism: intercalation‐mediated DNA damage and targeted inhibition of EGFR, leading to cell cycle arrest and mitotic catastrophe. ABSTRACT Glioblastoma multiforme (GBM) is an aggressive, therapy‐resistant brain tumor with limited treatment options.
Jianzheng Huang +12 more
wiley +1 more source
Copper‐Catalyzed Synthesis of Benzimidazole‐Fused Phenanthridines and Quinolines
A modular synthetic method for benzimidazole‐fused phenanthridines, benzo[4,5]imidazo[1,2‐ f ]phenanthridines, has been developed via copper‐catalyzed sequential C(sp 2
Seong Weon Lee, Chan Sik Cho
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, 2022 This report developed a method for the synthesis of C8-aminated pyrrolo-phenanthridines or -indoles by series ortho C(sp2)–H amination/ipso C(sp2)–H or C(sp3)–H arylation.
Xue-Ya Gou +15 more
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Information &Functional Materials, Volume 3, Issue 1, Page 35-46, March 2026.A new molecular cocrystal shows D‐A alternative molecular stacking, cyan‐blue photoluminescence with lifetime of 19.76 ns, and two‐photon absorption enabled emission under laser excitation between 720 and 880 nm. Theoretical calculations reveal its static dipole moment of 2.84 D, CT character in the ground, S1, and S2 excited states, and the TPA ...
Weigang Zhu +4 more
wiley +1 more source
, 2016 Aromatic aldehydes reacted with anilines and benzenediazonium-2-carboxylate to afford 6-aryl-phenanthridines. The reaction furnishes a rapid and direct construction of substituted phenanthridine rings from readily available starting materials via a one ...
Yun-Yun Yang (2438551) +2 more
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, 2022 International audienceThe Pd-catalyzed annulative pi-extension reaction of 1-arylimidazoles for the one pot preparation of imidazo[1,5-f]phenanthridines was explored. The higher reactivity of imidazole C5-H bond compared to C2-H bond of imidazoles for Pd-
Liu, Linhao +5 more
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, 2015 A new and convenient method for the synthesis of indolo[1,2-f]phenanthridines via palladium-catalyzed domino C-N coupling/hydroamination/C-H arylation reactions was developed.
Ngo, T.N. +4 more
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, 2023 Herein, an N-heterocyclic carbene (NHC)-catalyzed tandem cyclization/addition/cyclization reaction of 2-isocyanobiaryls and α-bromo-N-cinnamylamides for the synthesis of 2-pyrrolidinone-functionalized phenanthridines is developed.
Nengneng Zhou (2287066) +5 more
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Studies in the phenanthridine series. Part VI. A synthesis of 3-methyl phenanthridine
Journal and proceedings of the Royal Society of New South Wales, 1945 (Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
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