Paradoxical effects of the topoisomerase inhibitor, ethoxidine, in the cellular processes leading to angiogenesis on EaHy.926 endothelial cells [PDF]
, 2010 Topoisomerase I generates transient single-stranded breaks in DNA and have the capacity to fragment the genome. Thus, this enzyme is the target for some of the most successful anticancer drugs.
J.J. Helesbeux +4 more
core +2 more sources
The phytogenic feed additive Sangrovit modulates dextran sulfate sodium-induced colitis in rats
Veterinární Medicína, 2010 The alkaloids of Macleaya cordata (Papaveracae) are active components of the phytogenic feed additive Sangrovit. The present study was conducted to evaluate the effects of Sangrovit on dextran sulfate sodium (DSS)-induced colitis using rats as an ...
E. Vrublova +9 more
doaj +1 more source
Comparing the rate of growth and metabolic efficiency of yeast experiencing environmental stress or genetic damage [PDF]
, 2013 Physical stresses, toxic substances, and mutations can cause marked decline in the rate of growth (RG). We report that the efficiency of growth (EG), i.e. converting glucose into biomass, responds less profoundly.
Jakubowska, Agata +2 more
core +1 more source
MitoNeoD:a mitochondria-targeted superoxide probe [PDF]
, 2017 Mitochondrial superoxide (O2⋅−) underlies much oxidative damage and redox signaling. Fluorescent probes can detect O2⋅−, but are of limited applicability in vivo, while in cells their usefulness is constrained by side reactions and DNA intercalation.
Anderson, Robert F. +19 more
core +5 more sources
Mo–Catalyzed One-Pot Synthesis of N-Polyheterocycles from Nitroarenes and Glycols with Recycling of the Waste Reduction Byproduct. Substituent-Tuned Photophysical Properties [PDF]
, 2021 A catalytic domino reduction–imine formation– intramolecular cyclization–oxidation for the general synthesis of a wide variety of biologically relevant N-polyheterocycles, such as quinoxaline- and quinoline-fused derivatives, and phenanthridines, is ...
Fernández Rodríguez, Manuel A. +6 more
core +1 more source
Chemistry – A European Journal, EarlyView.Why add another catalyst when the product itself holds the power to catalyze its own formation? Autocatalysis in synthetic chemistry enhances reaction efficiency and uncovers novel catalytic behavior across both closed‐shell and open‐shell systems, expanding reactivity and enabling innovative design strategies.
Jaspreet Kaur, Joshua P. Barham
wiley +1 more source
A radical addition/cyclization of diverse ethers to 2-isocyanobiaryls under mildly basic aqueous conditions [PDF]
, 2016 Mildly basic aqueous conditions facilitated the tert-butyl peroxybenzoate (TBPB) mediated dehydrogenative addition of a range of ethers, including acetals, to diverse substituted 2-isocyanobiaryls. Mechanistic studies suggest that this radical cascade is
Anton-Torrecillas, Cintia +2 more
core +2 more sources
Synthesis and Characterization of Carbazole‐Containing Aza[7]helicenes
Chemistry – A European Journal, EarlyView.Double ortho fusion led to different aza[7]helicene frameworks showing strong acidochromic behavior, singlet excited energies being more than twice the triplet energy, and high racemization barriers, allowing chiral resolution and ECD measurements. ABSTRACT Azahelicenes have attracted significant interest due to their intrinsic axial chirality and ...
Inka Marten +2 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.Monosubstituted N‐arylhydroxylamines represent a unique subclass of hydroxylamines that act as pivotal intermediates in redox transformations and as versatile platforms for further synthetic transformations. They serve as key building blocks in the synthesis of architecturally complex heterocycles and other valuable organic compounds.
Michael G. Kallitsakis +2 more
wiley +1 more source