Results 151 to 160 of about 17,878 (169)
Some of the next articles are maybe not open access.
Journal of Medicinal Chemistry, 1987
In a further investigation of electron-deficient DNA-intercalating ligands as antitumor drugs, a series of substituted N-[2-(dimethylamino)ethyl]phenazine-1-carboxamides have been synthesized and evaluated. Fluorine-directed ring closure of N-phenyl-3-nitroanthranilic acids provided a new, unequivocal synthesis of several of the required phenazine-1 ...
G W, Rewcastle, W A, Denny, B C, Baguley
openaire +2 more sources
In a further investigation of electron-deficient DNA-intercalating ligands as antitumor drugs, a series of substituted N-[2-(dimethylamino)ethyl]phenazine-1-carboxamides have been synthesized and evaluated. Fluorine-directed ring closure of N-phenyl-3-nitroanthranilic acids provided a new, unequivocal synthesis of several of the required phenazine-1 ...
G W, Rewcastle, W A, Denny, B C, Baguley
openaire +2 more sources
Biopolymers, 2014
ABSTRACTMLN 944 is a bisintercalating DNA‐binding antitumor agent known to be a template inhibitor of transcription. Previous 1H NMR studies of its d(ATGCAT)2 complex concluded that its phenazine chromophores are protonated. However, we find that this is not so, which has important consequences for the charged state of the ligand, for the orientation ...
A. Serobian +4 more
semanticscholar +3 more sources
ABSTRACTMLN 944 is a bisintercalating DNA‐binding antitumor agent known to be a template inhibitor of transcription. Previous 1H NMR studies of its d(ATGCAT)2 complex concluded that its phenazine chromophores are protonated. However, we find that this is not so, which has important consequences for the charged state of the ligand, for the orientation ...
A. Serobian +4 more
semanticscholar +3 more sources
Pest Management Science
Phenazine‐1‐carboxamide (PCN) is a new fungicide; however, the number of its inhibitory targets is unknown. The target genes were identified by high‐throughput screening, reverse molecular docking, drug‐target binding, molecular dynamics, RNA ...
Shuangqing Liu +7 more
semanticscholar +1 more source
Phenazine‐1‐carboxamide (PCN) is a new fungicide; however, the number of its inhibitory targets is unknown. The target genes were identified by high‐throughput screening, reverse molecular docking, drug‐target binding, molecular dynamics, RNA ...
Shuangqing Liu +7 more
semanticscholar +1 more source
ChemInform, 1987
AbstractUllmann reaction between the anilines (I) and the 3‐nitrobenzoic acids (II) gives the products (III).
G. W. REWCASTLE +2 more
openaire +1 more source
AbstractUllmann reaction between the anilines (I) and the 3‐nitrobenzoic acids (II) gives the products (III).
G. W. REWCASTLE +2 more
openaire +1 more source
Journal of Inorganic Biochemistry, 2000
A series of intercalator-tethered platinum(II) complexes PtLCl2 have been prepared, where L are the diamine ligands N-[2-[(aminoethyl)amino]ethyl]-phenazine-1-carboxamide, N-[3-[(2-aminoethyl)amino]propyl]-phenazine-1-carboxamide, N-[4-[(2-aminoethyl)amino]butyl]-phenazine-1-carboxamide and N-[5-[(aminoethyl)amino]pentyl]-phenazine-1-carboxamide ...
Perrin, Leah C. +5 more
openaire +3 more sources
A series of intercalator-tethered platinum(II) complexes PtLCl2 have been prepared, where L are the diamine ligands N-[2-[(aminoethyl)amino]ethyl]-phenazine-1-carboxamide, N-[3-[(2-aminoethyl)amino]propyl]-phenazine-1-carboxamide, N-[4-[(2-aminoethyl)amino]butyl]-phenazine-1-carboxamide and N-[5-[(aminoethyl)amino]pentyl]-phenazine-1-carboxamide ...
Perrin, Leah C. +5 more
openaire +3 more sources
Journal of Medicinal Chemistry, 2000
Ring-substituted bis(phenazine-1-carboxamides), linked by a -(CH(2))(3)NMe(CH(2))(3)- chain, were prepared from the corresponding substituted phenazine-1-carboxylic acids by reaction of the intermediate imidazolides with bis(3-aminopropyl)methylamine. The compounds were evaluated for growth inhibitory activity in a panel of tumor cell lines, including ...
J A, Spicer +6 more
openaire +2 more sources
Ring-substituted bis(phenazine-1-carboxamides), linked by a -(CH(2))(3)NMe(CH(2))(3)- chain, were prepared from the corresponding substituted phenazine-1-carboxylic acids by reaction of the intermediate imidazolides with bis(3-aminopropyl)methylamine. The compounds were evaluated for growth inhibitory activity in a panel of tumor cell lines, including ...
J A, Spicer +6 more
openaire +2 more sources
Journal of Applied Microbiology, 2010
To purify and characterize an antimicrobial compound produced by a biocontrol bacterium, Pseudomonas aeruginosa MML2212, and evaluate its activity against rice pathogens, Rhizoctonia solani and Xanthomonas oryzae pv. oryzae.Pseudomonas aeruginosa strain MML2212 isolated from the rice rhizosphere with wide-spectrum antimicrobial activity was cultured in
V. Shanmugaiah +2 more
semanticscholar +3 more sources
To purify and characterize an antimicrobial compound produced by a biocontrol bacterium, Pseudomonas aeruginosa MML2212, and evaluate its activity against rice pathogens, Rhizoctonia solani and Xanthomonas oryzae pv. oryzae.Pseudomonas aeruginosa strain MML2212 isolated from the rice rhizosphere with wide-spectrum antimicrobial activity was cultured in
V. Shanmugaiah +2 more
semanticscholar +3 more sources
Bioorganic & Medicinal Chemistry, 2006
A series of phenazine-1-carboxamides were prepared, including variations in both chromophore substituents and the nature of the cationic side chain. The novel side-chain analogues were prepared from the corresponding phenazine-1-carboxylic acids via Schmidt conversion to the 1-amines and from the corresponding 1-halides.
Swarna A, Gamage +4 more
openaire +2 more sources
A series of phenazine-1-carboxamides were prepared, including variations in both chromophore substituents and the nature of the cationic side chain. The novel side-chain analogues were prepared from the corresponding phenazine-1-carboxylic acids via Schmidt conversion to the 1-amines and from the corresponding 1-halides.
Swarna A, Gamage +4 more
openaire +2 more sources
Bioorganic & Medicinal Chemistry, 2001
QSAR have been developed for the anticancer activity (growth inhibition) of various tumor cells by bis(11-oxo-11H-indeno[1,2-b]quinoline-6-carboxamides), bis(phenazine-1-carboxamides), and bis(naphthalimides). Of the seven QSAR, positive hydrophobic interactions are found in only two examples: bis(naphthalimides) versus human colon cancer cells.
S B, Mekapati +3 more
openaire +2 more sources
QSAR have been developed for the anticancer activity (growth inhibition) of various tumor cells by bis(11-oxo-11H-indeno[1,2-b]quinoline-6-carboxamides), bis(phenazine-1-carboxamides), and bis(naphthalimides). Of the seven QSAR, positive hydrophobic interactions are found in only two examples: bis(naphthalimides) versus human colon cancer cells.
S B, Mekapati +3 more
openaire +2 more sources
2013
Tomato foot and root rot (TFRR) is a tomato root disease caused by the fungus Fusarium oxysporum f. sp. radicis-lycopersici (Forl). No chemicals are available which efficiently suppress TFRR. In this chapter we show that the bacterium Pseudomonas chlororaphis strain PCL1391 is able to suppress the disease.
Ben Lugtenberg, Geneviève Girard
openaire +1 more source
Tomato foot and root rot (TFRR) is a tomato root disease caused by the fungus Fusarium oxysporum f. sp. radicis-lycopersici (Forl). No chemicals are available which efficiently suppress TFRR. In this chapter we show that the bacterium Pseudomonas chlororaphis strain PCL1391 is able to suppress the disease.
Ben Lugtenberg, Geneviève Girard
openaire +1 more source