Results 151 to 160 of about 19,721 (205)
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Jacep, 1978
The potential for a pharmacologic "overdose" and the cause of death associated with phencyclidine abuse is discussed. Nineteen deaths associated exclusively with phencyclidine intoxication have been documented. In 13 cases the immediate cause of death was asphyxia by drowning or trauma with lower levels of phencyclidine present suggesting behavioral ...
R S, Burns, S E, Lerner
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The potential for a pharmacologic "overdose" and the cause of death associated with phencyclidine abuse is discussed. Nineteen deaths associated exclusively with phencyclidine intoxication have been documented. In 13 cases the immediate cause of death was asphyxia by drowning or trauma with lower levels of phencyclidine present suggesting behavioral ...
R S, Burns, S E, Lerner
exaly +3 more sources
Emergency Medicine Clinics of North America, 1990
Patients intoxicated with phencyclidine (PCP) present both diagnostic and management dilemmas. The clinical presentation ranges from coma to severe agitation and violence; disorientation, psychosis, catatonia and bizarre behavior can be seen. Patients are at-risk for significant medical complications such as rhabdomyolysis, seizures, and hyperthermia ...
E B, Baldridge, H A, Bessen
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Patients intoxicated with phencyclidine (PCP) present both diagnostic and management dilemmas. The clinical presentation ranges from coma to severe agitation and violence; disorientation, psychosis, catatonia and bizarre behavior can be seen. Patients are at-risk for significant medical complications such as rhabdomyolysis, seizures, and hyperthermia ...
E B, Baldridge, H A, Bessen
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Biotransformation of Phencyclidine
Drug Metabolism Reviews, 1985PCP is metabolized extensively in the body via a variety of metabolic routes. Biotransformation is a major mechanism of PCP elimination in humans and termination of PCP action in mice. In general, PCP metabolites are less active pharmacologically than PCP itself.
E J, Holsztynska, E F, Domino
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Clinical Toxicology, 1976
The results of the animal experiment demonstrate that oxidative hydroxylation is the major mode of metabolism of phencyclidine. It is evident that this process takes place in all three rings of the molecule. Hydroxylation of the piperidyl moiety probably also accounts for the formation of the N-dealkylated metabolites.
L K, Wong, K, Biemann
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The results of the animal experiment demonstrate that oxidative hydroxylation is the major mode of metabolism of phencyclidine. It is evident that this process takes place in all three rings of the molecule. Hydroxylation of the piperidyl moiety probably also accounts for the formation of the N-dealkylated metabolites.
L K, Wong, K, Biemann
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Phencyclidine and phenylcyclohexene disposition after smoking phencyclidine
Clinical Pharmacology and Therapeutics, 1982Five men who smoked parsley cigarettes containing 100 micrograms of [3H]-phencyclidine hydrochloride (PCP.HCl) inhaled 69 +/- 5(SEM) % of the total radioactivity in the cigarette. Both PCP and its pyrolysis product, 1-phenylcyclohexene (PC), were found and measured in plasma. Calculations based on the assumption that the ratio of these two products was
C E, Cook +4 more
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2000
Abstract Phencyclidine (PCP) is an odorless, white, crystalline sub stance. Pure PCP has a MW of 243.9, a MP of 234°-236°C, and is highly insoluble in water. The most frequently encountered form of PCP is the hydrochloride salt, which has a MW of 279.9 and is soluble in both water and ethanol.
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Abstract Phencyclidine (PCP) is an odorless, white, crystalline sub stance. Pure PCP has a MW of 243.9, a MP of 234°-236°C, and is highly insoluble in water. The most frequently encountered form of PCP is the hydrochloride salt, which has a MW of 279.9 and is soluble in both water and ethanol.
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