Results 171 to 180 of about 6,115 (220)

A review of phenformin, metformin, and imeglimin

Drug development research (Print), 2020
Diabetes mellitus is a serious metabolic disorder affecting millions of people worldwide. Phenformin and metformin are biguanide antidiabetic agents that are conveniently synthesized in a single‐step chemical reaction.
R. Yendapally, D. Sikazwe, Subin S Kim, S. Ramsinghani, Rheaclare Fraser‐Spears, Amy P. Witte, Brittany La-Viola   +6 more
semanticscholar   +1 more source

Phenformin and Pancreatitis

Annals of Internal Medicine, 1973
Excerpt To the editor: The letter by Dr. Wilde (1), which raises the question of a causal association of phenformin and pancreatitis, prompts me to report a case of pancreatitis in association with...
E, Coodley, J, Derasse, J, Carver
openaire   +4 more sources

Chondroitin Sulfate-Derived Micelles for Adipose Tissue-Targeted Delivery of Celastrol and Phenformin to Enhance Obesity Treatment.

ACS Applied Bio Materials
Adipose tissue macrophages (ATMs) are crucial in maintaining a low-grade inflammatory microenvironment in adipose tissues (ATs). Modulating ATM polarization to attenuate inflammation represents a potential strategy for treating obesity with insulin ...
Yining Niu, Tingting Gao, Hongling Ouyang, Yunxiao Zhang, T. Gong, Zhirong Zhang, Xi Cao, Yao Fu   +7 more
semanticscholar   +1 more source

Phenformin-Associated Lactic Acidosis Due to Imported Phenformin

Diabetes Care, 1996
OBJECTIVE To emphasize the continued incidence of phenformin-associated lactic acidosis. CASE REPORT We report a case of phenformin-associated lactic acidosis in a Chinese man who received phenformin while in China.
H C, Lu, P P, Parikh, D L, Lorber
openaire   +2 more sources

Phenformin-Associated Pancreatitis

Annals of Internal Medicine, 1977
Although phenformin has been previously reported to be associated with acute pancreatitis, little emphasis of this association has been made in the literature. We report the case of a 70-year-old diabetic man who developed acute hemorrhagic pancreatitis and severe lactic acidosis while taking phenformin. The patient was not taking any other medications,
H S, Chase, G R, Mogan
openaire   +2 more sources

Phenformin-associated metabolic acidosis

Diabetes, 1976
We report 18 consecutive phenformin-treated diabetic patients admitted to this Medical Service acutely ill with metabolic acidosis. Lactic acidosis was anticipated, and documented, in all. Also, however, though most of the patients had only weakly positive, or even negative, serum reactions with the nitroprusside reagent, all were found to have ...
M, Fulop, H D, Hoberman
openaire   +2 more sources

Serum Phenformin Concentrations in Patients with Phenformin-associated Lactic Acidosis

Diabetes, 1977
Phenformin concentrations were measured in serum from seven patients with phenformin-associated lactic acidosis, and initial values ranging from 20 to 625 ng./ml. were obtained. Five of the seven patients had serum concentrations within the usual therapeutic range of up to 241 ng./ml. Serum phenformin concentrations were measured serially, and apparent
L A, Conlay, J H, Karam, S B, Matin, J E, Loewenstein   +3 more
openaire   +2 more sources

Exploring metabolic reprogramming in melanoma via acquired resistance to the oxidative phosphorylation inhibitor phenformin

Melanoma research, 2020
Supplemental Digital Content is available in the text. Therapeutic failures in cancer therapy are often associated with metabolic plasticity. The use of metabolic modulators as anti-cancer agents has been effective in correcting metabolic alterations ...
M. Pistoni, Giulia Tondelli, Cristina Gallo, F. Torricelli, Alessandra Maresca, V. Carelli, A. Ciarrocchi, K. Dallaglio   +7 more
semanticscholar   +1 more source

Thermodynamic Solubility and Mixing Properties of Phenformin in 14 Pure Solvents at Temperatures Ranging from 278.15 to 323.15 K

Journal of Chemical and Engineering Data, 2019
The equilibrium solubility of phenformin in 14 solvents of N,N-dimethylformamide (DMF), N-methyl-2-pyrrolidinone (NMP), dimethyl sulfoxide (DMSO), methanol, isopropanol, ethanol, n-propanol, 1,4-dioxane, n-butanol, isobutanol, acetonitrile, ethyl acetate,
Xi Zhao, Gui Han, Hongkun Zhao
semanticscholar   +1 more source

PHENFORMIN AND METABOLIC ACIDOSIS

The Lancet, 1972
Abstract A patient with oliguric renal failure complicating accelerated hypertension was given phenformin and ethylœstrenol as fibrinolytic therapy. On the fifth day of this treatment a profound and fatal metabolic acidosis developed despite good control of uraemia by peritoneal dialysis. The acidosis was resistant to 2500 meq.
G A, MacGregor, P A, Poole-Wilson, N F, Jones   +2 more
openaire   +2 more sources