Results 191 to 200 of about 36,304 (274)

Membralin Assembles a MAN1B1–VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation

Advanced Science, EarlyView.
This study identifies Membralin as an ER‐phagy receptor that recruits MAN1B1 and VCP to form a selective ERLAD complex. By sensing dense N‐glycan clusters on viral fusion glycoproteins, this ubiquitin‐independent pathway directs SARS‐CoV‐2 spike, Ebola GP, influenza HA, and HIV‐1 Env to lysosomal degradation, thereby limiting viral infectivity ...
Jing Zhang, Xiaoran Lu, Sunan Li, Tao Wang, Iqbal Ahmad, Yong‐Hui Zheng   +5 more
wiley   +1 more source

Cannabidiol combined with GABAergic drugs but not with sodium channel blockers prevents the development of drug-resistance seizures in a preclinical model. [PDF]

Front Pharmacol
Fuentes-Mejia M, Fallico MJ, Talevi A, Gavernet L, Orozco-Suárez SA, Rocha L.   +5 more
europepmc   +1 more source

Direct Extracellular Matrix Modulation Attenuates Intestinal Fibrosis via a Fibronectin‐Targeted Approach

Advanced Science, EarlyView.
Fibronectin regulates the extracellular matrix (ECM)–myofibroblast cycle through three key steps: (1) its secretion and assembly by myofibroblasts (inhibited by pUR4); (2) collagen deposition along its scaffold (inhibited by R1R2); and (3) integrin α5β1‐mediated mechanotransduction (inhibited by ATN161).
Wenlong Ma, Siyu Yang, Tengkai Wang, Di Zhang, Hewei Wu, Shichen Fu, Xiaohan Wan, Lixiang Li, Xiuli Zuo, Yanqing Li, Jiaoyang Lu   +10 more
wiley   +1 more source

Clinical and genotypic characteristics of 19 children with STXBP1-encephalopathy. [PDF]

Medicine (Baltimore)
Qi L, Fang C, Hu Z.
europepmc   +1 more source

Efficacy and Pharmacokinetics of Intravenous Phenobarbital Maintenance Therapy for Status Epilepticus and Cluster Seizures in Childhood

, 2012
Kenjiro Kikuchi, Shin-ichiro Hamano, Ryuki Matsuura, Kotoko Suzuki, Manabu Tanaka, Motoyuki Minamitani, Hiroyuki Ida   +6 more
openalex   +1 more source

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source

Cannabidiol potentiates phenobarbital effects in the control of pentylenetetrazole (PTZ)-induced epileptic seizures in neonate rats. [PDF]

Front Pediatr
Pinto LS, de Oliveira MS, Borges GB, de Castro OW, Moreira FA, Santos VR.   +5 more
europepmc   +1 more source

Effects of Phenobarbital, 3-Methylcholanthrene, and Hematin on the Synthesis of Protein Components of Rat Liver Microsomal Membranes

, 1972
Peter J. Dehlinger, Robert Schimke
openalex   +1 more source

SAGE: Spatially Aware Gene Selection and Dual‐View Embedding Fusion for Domain Identification in Spatial Transcriptomics

Advanced Science, EarlyView.
SAGE is a unified framework for spatial domain identification in spatial transcriptomics that jointly models tissue architecture and gene programs. Topic‐driven gene selection (NMF plus classifier‐based scoring) highlights spatially informative genes, while dual‐view graph embedding fuses local expression and non‐local functional relations.
Yi He, Yunpei Xu, Liqing Ding, Hong‐Dong Li, Yaohang Li, Shaokai Wang   +5 more
wiley   +1 more source

Pharmacometrics modeling and simulation to assist phenobarbital dose optimization in dogs. [PDF]

Front Vet Sci
Alvariza S, Ibarra M, Guevara N, Maldonado C, Vázquez M, Feijoó G, Suárez G.   +6 more
europepmc   +1 more source