Results 271 to 280 of about 78,657 (383)

Self‐limited familial focal epilepsy caused by ANK2 variants: A potentially under‐recognized condition

open access: yesEpilepsia Open, EarlyView.
Abstract The Ankyrin 2 (ANK2) gene encodes the ankyrin‐B protein (ANKB), which is involved in the organization and stability of membrane ion channels, transporters, and receptors in cardiomyocytes and neurons. Variants in ANK2 genes are initially reported in long QT syndrome and autism.
Po‐Hsi Lin   +5 more
wiley   +1 more source

Interim analysis of the long‐term efficacy and safety of azetukalner in an ongoing open‐label extension study following a phase 2b clinical trial (X‐TOLE) in adults with focal epilepsy

open access: yesEpilepsia Open, EarlyView.
Abstract Objective To report interim data from an ongoing, open‐label extension (OLE) of a Phase 2b study (X‐TOLE) of azetukalner in adults with focal onset seizures (FOS) receiving 1–3 antiseizure medications. Methods Eligible participants enrolled in the 7‐year OLE at 20 mg azetukalner once daily with food.
Jacqueline A. French   +62 more
wiley   +1 more source

Excretion of organic acids associated with biotin deficiency in chronic anticonvulsant therapy [PDF]

open access: yes, 1984
Berlit, Peter   +3 more
core  

Efficacy and tolerability of low versus standard daily doses of antiseizure medications in newly diagnosed focal epilepsy. A multicenter, randomized, single‐blind, non‐inferiority trial (STANDLOW)

open access: yesEpilepsia Open, EarlyView.
Abstract Objective The STANDLOW trial investigated whether first‐line antiseizure monotherapy with low doses has a similar efficacy to standard doses, but with fewer adverse events, improved quality of life, and reduced costs for the National Health System.
Giorgia Giussani   +50 more
wiley   +1 more source

Efficacy of phenobarbital is maintained after exposure to mild‐to‐moderate seizures in neonates

open access: yesEpilepsia Open, EarlyView.
Abstract To study the relationship between the delay in treatment and the efficacy of phenobarbital in neonates, we re‐analyzed data from the NEOLEV2 study. Continuous video EEG (cEEG) from patients treated with phenobarbital was reviewed by neurophysiologists who marked each seizure.
Cynthia Sharpe   +9 more
wiley   +1 more source

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