Results 331 to 340 of about 78,657 (383)
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Toxicology, 1987
Male Sprague-Dawley rats were treated with clofibrate (CLOF) in the diet for 2 years or with 4 i.p. injections of either diethylnitrosamine (DEN) or benzidine (BZ) followed by phenobarbital (PB) in the diet for 67 weeks, or just with PB for 41 weeks. Animals were killed at frequent intervals, some while still on treatment and others after 3 or 6 months
Paul R. Mompon +4 more
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Male Sprague-Dawley rats were treated with clofibrate (CLOF) in the diet for 2 years or with 4 i.p. injections of either diethylnitrosamine (DEN) or benzidine (BZ) followed by phenobarbital (PB) in the diet for 67 weeks, or just with PB for 41 weeks. Animals were killed at frequent intervals, some while still on treatment and others after 3 or 6 months
Paul R. Mompon +4 more
openaire +3 more sources
Journal of Separation Science, 2018
A modified dispersive liquid phase microextraction based on sequential injection solidified floating organic drop was developed for simultaneous separation/preconcentration of trace amounts of phenobarbital and phenytoin.
Arezou Amiri Pebdani +4 more
semanticscholar +1 more source
A modified dispersive liquid phase microextraction based on sequential injection solidified floating organic drop was developed for simultaneous separation/preconcentration of trace amounts of phenobarbital and phenytoin.
Arezou Amiri Pebdani +4 more
semanticscholar +1 more source
Mechanism of Phenobarbital Degradation
Journal of Pharmaceutical Sciences, 1962Previous studies on the degradation of barbiturates have indicated that the products of hydrolysis of the ionic and nonionic forms might be different. During the course of a study on the analysis of phenobarbital it was discovered that one of the postulated products (phenylethylacetylurea) could be determined in the presence of phenobarbital ...
Jere E. Goyan +2 more
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, 2017
The preferential solvation parameters of phenobarbital in aqueous binary mixtures of 1,4-dioxane, t-butanol, n-propanol, ethanol, propylene glycol and glycerol were derived from solution thermodynamic properties by using the IKBI method.
F. Martínez, A. Jouyban, W. E. Acree
semanticscholar +1 more source
The preferential solvation parameters of phenobarbital in aqueous binary mixtures of 1,4-dioxane, t-butanol, n-propanol, ethanol, propylene glycol and glycerol were derived from solution thermodynamic properties by using the IKBI method.
F. Martínez, A. Jouyban, W. E. Acree
semanticscholar +1 more source
Clinical Pharmacology of Phenobarbital in Neonates: Effects, Metabolism and Pharmacokinetics.
Current pediatric reviews, 2016Phenobarbital is an effective and safe anticonvulsant drug introduced in clinical use in 1904. Its mechanism of action is the synaptic inhibition through an action on GABAA.
G. Pacifici
semanticscholar +1 more source
ChemInform Abstract: BENZOYLATION OF PHENOBARBITAL
Chemischer Informationsdienst, 1980AbstractDie Benzoylierung von Phenobarbital (5‐Phenyl‐5‐ ethyl‐barbitursäure) (I) wird technisch so durchgeführt, daß (I) mit Benzoylchlorid (II) in Gegenwart von Pyridin auf 120 ‐ 122°C erwärmt wird, wobei man die gewünschte 1‐Benzoyl‐5‐phenyl‐5‐ethyl‐barbitursäure (Benzonal) (III) mit nur 40% Ausbeute erhält.
L. Kh. Vinograd +2 more
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Phenobarbital for neonatal jaundice
The Journal of Pediatrics, 1970T H I S C O M M E N T A R Y is prompted by an increasing number of inquiries as to whether it is now indicated to treat hyperbilirubinemia with phenobarbital during the first week of life. In 1968 Catz and Yaffee 1 demonstrated that the conjugation and excretion of bilirubin could be increased significantly in newborn animals by giving sodium barbital ...
David E Fisher, Richard E. Behrman
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Acetazolamide in Phenobarbital Intoxication
Archives of Internal Medicine, 1966THE BARBITURATES can be divided into two groups on the basis of their metabolism. One group is metabolized primarily by the liver. The short-acting drugs, in general, fit into this group. The second group comprises those barbiturates in which elimination of the active agent is primarily by renal excretion with inactivation by the liver being of less ...
Morton F. Mason +3 more
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Evaluation of Subcutaneous Phenobarbital Administration in Hospice Patients
The American journal of hospice & palliative care, 2016Phenobarbital is used in hospice and palliative care to treat refractory symptoms. In end-of-life care, Food and Drug Administration approved routes of administration may be unreasonable based on patients’ status.
Jessica Richards Hosgood +3 more
semanticscholar +1 more source
Determination of phenobarbital by radioimmunoassay
Journal of Immunological Methods, 1979A radioimmunoassay for phenobarbital has been studied. Antiphenobarbital antisera were obtained by repeated immunization of rabbits with p-succinamidophenobarbital conjugated to bovine serum albumin. Less than 0.2 pmol of phenobarbital could be measured by this procedure.
Takehiko Takatori, Aiko Yamaoka
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