Results 331 to 340 of about 86,047 (385)
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The Annals of Pharmacotherapy, 2020
Background Benzodiazepine is first-line therapy for alcohol withdrawal syndrome (AWS), and phenobarbital is an alternative therapy. However, its use has not been well validated in the surgical-trauma patient population.
Mahmoud A. Ammar +4 more
semanticscholar +1 more source
Background Benzodiazepine is first-line therapy for alcohol withdrawal syndrome (AWS), and phenobarbital is an alternative therapy. However, its use has not been well validated in the surgical-trauma patient population.
Mahmoud A. Ammar +4 more
semanticscholar +1 more source
Journal of Intensive Care Medicine, 2018
Background: Alcohol withdrawal syndrome (AWS) is a common reason for admission to a medical intensive care unit (MICU) and requires significant hospital resource utilization. Benzodiazepines are first-line therapy for AWS in many intensive care units. We
Margarita Oks +7 more
semanticscholar +1 more source
Background: Alcohol withdrawal syndrome (AWS) is a common reason for admission to a medical intensive care unit (MICU) and requires significant hospital resource utilization. Benzodiazepines are first-line therapy for AWS in many intensive care units. We
Margarita Oks +7 more
semanticscholar +1 more source
Toxicology, 1987
Male Sprague-Dawley rats were treated with clofibrate (CLOF) in the diet for 2 years or with 4 i.p. injections of either diethylnitrosamine (DEN) or benzidine (BZ) followed by phenobarbital (PB) in the diet for 67 weeks, or just with PB for 41 weeks. Animals were killed at frequent intervals, some while still on treatment and others after 3 or 6 months
Paul R. Mompon +4 more
openaire +3 more sources
Male Sprague-Dawley rats were treated with clofibrate (CLOF) in the diet for 2 years or with 4 i.p. injections of either diethylnitrosamine (DEN) or benzidine (BZ) followed by phenobarbital (PB) in the diet for 67 weeks, or just with PB for 41 weeks. Animals were killed at frequent intervals, some while still on treatment and others after 3 or 6 months
Paul R. Mompon +4 more
openaire +3 more sources
Mechanism of Phenobarbital Degradation
Journal of Pharmaceutical Sciences, 1962Previous studies on the degradation of barbiturates have indicated that the products of hydrolysis of the ionic and nonionic forms might be different. During the course of a study on the analysis of phenobarbital it was discovered that one of the postulated products (phenylethylacetylurea) could be determined in the presence of phenobarbital ...
Jere E. Goyan +2 more
openaire +4 more sources
ChemInform Abstract: BENZOYLATION OF PHENOBARBITAL
Chemischer Informationsdienst, 1980AbstractDie Benzoylierung von Phenobarbital (5‐Phenyl‐5‐ ethyl‐barbitursäure) (I) wird technisch so durchgeführt, daß (I) mit Benzoylchlorid (II) in Gegenwart von Pyridin auf 120 ‐ 122°C erwärmt wird, wobei man die gewünschte 1‐Benzoyl‐5‐phenyl‐5‐ethyl‐barbitursäure (Benzonal) (III) mit nur 40% Ausbeute erhält.
L. Kh. Vinograd +2 more
openaire +3 more sources
Acetazolamide in Phenobarbital Intoxication
Archives of Internal Medicine, 1966THE BARBITURATES can be divided into two groups on the basis of their metabolism. One group is metabolized primarily by the liver. The short-acting drugs, in general, fit into this group. The second group comprises those barbiturates in which elimination of the active agent is primarily by renal excretion with inactivation by the liver being of less ...
Morton F. Mason +3 more
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Acute Phenobarbital Intoxication
Southern Medical Journal, 1992Phenobarbital is a long-acting barbiturate often prescribed for seizure disorders. It has a high abuse potential and was commonly used in suicide attempts in the past. Although benzodiazepines are now more frequently used in suicide attempts, barbiturate intoxications are still occasionally seen and constitute a medical emergency.
Nancy Lindberg +2 more
openaire +2 more sources
Determination of phenobarbital by radioimmunoassay
Journal of Immunological Methods, 1979A radioimmunoassay for phenobarbital has been studied. Antiphenobarbital antisera were obtained by repeated immunization of rabbits with p-succinamidophenobarbital conjugated to bovine serum albumin. Less than 0.2 pmol of phenobarbital could be measured by this procedure.
Takehiko Takatori, Aiko Yamaoka
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Phenobarbital for neonatal jaundice
The Journal of Pediatrics, 1970T H I S C O M M E N T A R Y is prompted by an increasing number of inquiries as to whether it is now indicated to treat hyperbilirubinemia with phenobarbital during the first week of life. In 1968 Catz and Yaffee 1 demonstrated that the conjugation and excretion of bilirubin could be increased significantly in newborn animals by giving sodium barbital ...
David E Fisher, Richard E. Behrman
openaire +6 more sources
Phenobarbital in the Monitoring of Compliance
Annals of Internal Medicine, 1984Excerpt To the editor: In their review, Eraker and associates (1) rightly point out that pharmacokinetic differences between drugs and patients have greatly limited the usefulness of measurements o...
David C. Price +2 more
openaire +2 more sources