Results 341 to 350 of about 78,657 (383)

Simultaneous extraction and quantification of lamotrigine, phenobarbital, and phenytoin in human plasma and urine samples using solidified floating organic drop microextraction and high-performance liquid chromatography.

Journal of Separation Science, 2015
A novel and simple method based on solidified floating organic drop microextraction followed by high-performance liquid chromatography with ultraviolet detection has been developed for simultaneous preconcentration and determination of phenobarbital ...
M. Asadi, S. Dadfarnia, A. M. Haji Shabani, B. Abbasi   +3 more
semanticscholar   +1 more source

Acute Phenobarbital Intoxication

Southern Medical Journal, 1992
Phenobarbital is a long-acting barbiturate often prescribed for seizure disorders. It has a high abuse potential and was commonly used in suicide attempts in the past. Although benzodiazepines are now more frequently used in suicide attempts, barbiturate intoxications are still occasionally seen and constitute a medical emergency.
Nancy Lindberg, Michael C. Lindberg, Allison Cunningham   +2 more
openaire   +2 more sources

Accumulation of Phenobarbital in Man

Epilepsia, 1963
SUMMARYEquations relating serum concentrations of phenobarbital, dose/kg body weight, and rate of elimination were derived. Agreement between calculated and observed concentration‐time curves was obtained in 5 of 6 subjects, and between calculated and observed ratios of level to dose in 18 patients.
Fritz Buchthal, Ole Svensmark
openaire   +3 more sources

Phenobarbital in the Monitoring of Compliance

Annals of Internal Medicine, 1984
Excerpt To the editor: In their review, Eraker and associates (1) rightly point out that pharmacokinetic differences between drugs and patients have greatly limited the usefulness of measurements o...
David C. Price, Jonathan Cooke, Morgan Feely   +2 more
openaire   +2 more sources

Pharmacokinetics of phenobarbital in childhood

European Journal of Clinical Pharmacology, 1977
In 14 neonates 1-4 weeks old, 30 babies aged 1-12 months, and 7 infants of 1-5 years of age, the serum levels of phenobarbital were determined by a gas chromatographic micro-method after intravenous injection of phenobarbital 5-10 mg per kg body weight. It was possible to calculate the pharmacokinetic parameters using a two compartment open model.
Gladtke E, G Heimann
openaire   +3 more sources

Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures.

New England Journal of Medicine, 1985
We conducted a 10-center, double-blind trial to compare the efficacy and toxicity of four antiepileptic drugs in the treatment of partial and secondarily generalized tonic-clonic seizures in 622 adults.
R. Mattson, J. Cramer, J. Collins, D. B. Smith, A. Delgado-Escueta, T. Browne, P. Williamson, D. Treiman, J. McNamara, C. McCutchen   +9 more
semanticscholar   +1 more source

Quantitation of Phenobarbital and Phenobarbital Sodium in Pharmaceutical Dosage Forms

Journal of Pharmaceutical Sciences, 1984
A reverse-phase high-performance liquid chromatographic method for the quantitation of phenobarbital and phenobarbital sodium in pharmaceutical dosage forms (elixir, injection, and tablets) was developed. The method is precise and accurate with percent relative standard deviations of 0.9 (without an internal standard) and 0.7 (with an internal standard)
openaire   +3 more sources

Reaction of Phenobarbital with Diphenhydramine

Journal of Pharmaceutical Sciences, 1982
Abstract A compound of low water solubility, consisting of pheno- barbital-diphenhydramine in a 1:1 ratio and mp 109.5-110.5° was isolated from a prescription which had been dispensed as a clear solution and later returned with a white sediment. The information obtained suggested that it was either an easily dissociated complex or a salt.
Laurence M. Sirois, Melvin F.W. Dunker
openaire   +3 more sources

Purification and characterization of liver microsomal cytochromes p-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or beta-naphthoflavone.

Biochemistry, 1982
Eight different forms of cytochrome P-450 (P-450) were purified to electrophoretic homogeneity by a common procedure from liver microsomes of rats treated with phenobarbital or beta-naphthoflavone.
F. Guengerich, G. Dannan, S. Wright, M. Martín, L. Kaminsky   +4 more
semanticscholar   +1 more source

Identification of Phenobarbital N-Glucosides as Urinary Metabolites of Phenobarbital in Mice

Journal of Pharmaceutical Sciences, 1991
Previously, the N-glucosylation of phenobarbital had been observed only in humans. The results of a species screen (mouse, rat, guinea pig, rabbit, cat, dog, pig, and monkey) found that only mice excreted the N-glucosides of phenobarbital in urine after ip administration of sodium phenobarbital.
William H. Soine, Phyllis J. Soine, John W. Ferkany, Terry M. England, Bruce E. Agriesti   +4 more
openaire   +3 more sources