Results 351 to 360 of about 78,657 (383)
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2018
Phenobarbital and primidone are first-generation antiepileptic drugs currently associated with restricted ranges of antiepileptic indications, despite their acceptable interaction profiles in polytherapy. Although phenobarbital is still widely prescribed as antiepileptic drug in the developing world, safety issues (including risks of dependence and ...
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Phenobarbital and primidone are first-generation antiepileptic drugs currently associated with restricted ranges of antiepileptic indications, despite their acceptable interaction profiles in polytherapy. Although phenobarbital is still widely prescribed as antiepileptic drug in the developing world, safety issues (including risks of dependence and ...
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The phenobarbital sensitivity syndrome
The American Journal of Medicine, 1953Abstract 1.1. A syndrome of fever, delirium, exfoliative dermatitis and parenchymatous organ degeneration following administration of therapeutic amounts of phenobarbital is reviewed. 2.2. Three additional cases of phenobarbital idiosyncrasy are presented, two fatal and one with recovery. 3.3.
Thomas E. McGeachy, William E. Bloomer
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Phenobarbital pharmacokinetics in neonates
Clinical Pharmacology & Therapeutics, 1978Phenobarbital pharmacokinetics after intravenous injection were studied in 8 neonates with seizures. Subjects ranged in gestational age from 30 to 40 wk. Plasma concentrations of phenobarbital were measured by enzyme‐multiplied immunoassay (EMIT). The volume of distribution (Vd) of phenobarbital was 0.97 ± .15 L/kg which was independent of the dose ...
William H. Pitlick +2 more
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Suppression of Immunity by Phenobarbital
Nature New Biology, 1971PHENOBARBITAL, one of the more commonly used sedatives, behaves as an immunosuppressant in vivo and in vitro when prescribed in conventional, clinically acceptable doses. This observation closely followed experiments in this laboratory which showed that lymphocytes from all patients receiving general- anaesthesia during surgery developed impaired ...
J I Brody, Seungdoo Park
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Epilepsia, 2012
Phenobarbital (phenobarbitone) was first used as an antiepileptic drug 100 years ago, in 1912. This article tells the story of the discovery of its antiepileptic action, its early development, and the subsequent course of its clinical use over the 100 ...
Zeid Yasiry, S. Shorvon
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Phenobarbital (phenobarbitone) was first used as an antiepileptic drug 100 years ago, in 1912. This article tells the story of the discovery of its antiepileptic action, its early development, and the subsequent course of its clinical use over the 100 ...
Zeid Yasiry, S. Shorvon
semanticscholar +1 more source
Molecular Pharmacology, 2002
Phenobarbital (PB) induces various gene encoding drug/steroid-metabolizing enzymes such as cytochromes P450 (P450s) and transferases. Although the nuclear orphan constitutive active receptor (CAR) has been identified as a key transcription factor that ...
Akiko Ueda +7 more
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Phenobarbital (PB) induces various gene encoding drug/steroid-metabolizing enzymes such as cytochromes P450 (P450s) and transferases. Although the nuclear orphan constitutive active receptor (CAR) has been identified as a key transcription factor that ...
Akiko Ueda +7 more
semanticscholar +1 more source
Journal of Neurology Neurosurgery & Psychiatry, 2012
Background Phenobarbital is an effective treatment for epilepsy but concerns remain over its potential neurocognitive toxicity. This prospective study evaluated the effects of phenobarbital treatment on cognition and mood in people with epilepsy in rural
D. Ding +16 more
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Background Phenobarbital is an effective treatment for epilepsy but concerns remain over its potential neurocognitive toxicity. This prospective study evaluated the effects of phenobarbital treatment on cognition and mood in people with epilepsy in rural
D. Ding +16 more
semanticscholar +1 more source
Pharmacokinetics of phenobarbital in the horse
American Journal of Veterinary Research, 1987SUMMARY Pharmacokinetics of phenobarbital was examined in 6 mature horses after 12 mg of phenobarbital/kg of body weight was infused over 20 minutes. Biexponential decrease in serum phenobarbital concentrations was observed with a distribution-phase half-life of 0.101 ± 0.086 hour (mean ± sd) and a terminal-phase elimination half-life of 18.3 ± 3.65 ...
S H, Duran +3 more
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Phenobarbital-Associated Macroglossia
American Journal of Therapeutics, 2021Rukma Parthvi +2 more
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