Results 71 to 80 of about 449,273 (318)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Anaerobic treatment of phenol in a two-stage anaerobic reactor [PDF]

open access: yes, 2004
The inhibitory effects of phenol are problematic for the anaerobic treatment of wastewater. The purpose of this study is to demonstrate that a two-stage anaerobic digester (TSAD) can degrade phenol, reducing its toxic effects in the first acidogenic ...
Hernandez, J.E., Edyvean, R.G.J.
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

Use of Liquid Phenol for Management of Pilonidal Disease [PDF]

open access: yes, 2019
Introduction:This study describes the treatment of pilonidal sinus with liquid phenol and reports its short-term results.Methods:Patients with pilonidal disease were operated under local anesthesia. Primary and secondary pits were excised. Pilonidal cyst
Yüksel Karaköse, Alaattin Öztürk
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Use of Phenols, Peroxidase and Polyphenoloxidase of Seed to Quantify Resistance of Cotton Genotypes to Damping-off Incited by Fusarium oxysporum [PDF]

open access: yesJournal of Stress Physiology & Biochemistry, 2014
A greenhouse test was conducted in 2011 and 2012 growing seasons at Giza Agricultural Research Station to evaluate the reaction of six cotton genotypes to damping-off incited by Fusarium oxysporum. Damping-off incidence on the genotypes ranged from 70-88%
Heba I. Mohamed   +2 more
doaj  

A Study of the Interactions of Activated Carbon-Phenol in Aqueous Solution Using the Determination of Immersion Enthalpy

open access: yesApplied Sciences, 2018
In this study, the amount of phenol adsorbed between 0 and 10 mmol∙L−1 during an immersion calorimetric experiment is compared with the adsorption that takes place once phenol adsorption reaches the solid–solution equilibrium.
Ana María Carvajal-Bernal   +3 more
doaj   +1 more source

Effect of phenol on germination capacity and polyphenol oxidase, peroxidase and catalase activities in lettuce [PDF]

open access: yesArchives of Biological Sciences, 2014
In this study we examined the activities of polyphenol oxidase (PPO) and antioxidant enzymes, peroxidase (POX) and catalase (CAT) during lettuce seed germination at different concentrations of phenol.
Tadić Vojin   +6 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Paraplegia after intercostal neurolysis with phenol [PDF]

open access: yes, 2014
Lakshman Gollapalli, Rudramanaidu Muppuri Department of Anesthesiology and Pain Medicine, Wayne State University/Detroit Medical Center, Detroit, MI, USA Abstract: In patients with advanced stages of cancer, severe pain is commonly encountered and is ...
Gollapalli L, Muppuri R
core   +1 more source

Home - About - Disclaimer - Privacy